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Browse our Ubiquitin-Conjugating Enzyme E2D 1 Proteins (UBE2D1)

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Ubiquitin-Conjugating Enzyme E2D 1 Proteins (UBE2D1)
On are 19 Ubiquitin-Conjugating Enzyme E2D 1 (UBE2D1) Proteins from 10 different suppliers available. Additionally we are shipping Ubiquitin-Conjugating Enzyme E2D 1 Antibodies (64) and many more products for this protein. A total of 86 Ubiquitin-Conjugating Enzyme E2D 1 products are currently listed.
E2(17)KB1, SFT, UBC4/5, UBCH5, UBCH5A, ube2d1, wu:fc16h06, zgc:73096
list all proteins Gene Name GeneID UniProt
UBE2D1 7321 P51668
Mouse UBE2D1 UBE2D1 216080 P61080
UBE2D1 361831 D3ZDK2

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Ubiquitin-Conjugating Enzyme E2D 1 Proteins (UBE2D1) by Origin

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Top referenced Ubiquitin-Conjugating Enzyme E2D 1 Proteins

  1. Human UBE2D1 Primary Antibody for SDS - ABIN667460 : Pabarcus, Hoe, Sadeghi, Patterson, Wiertz, Correia: CYP3A4 ubiquitination by gp78 (the tumor autocrine motility factor receptor, AMFR) and CHIP E3 ligases. in Archives of biochemistry and biophysics 2009 (PubMed)
    Show all 2 references for ABIN667460

  2. Human UBE2D1 Primary Antibody for - ABIN2004281 : Grou, Carvalho, Pinto, Wiese, Piechura, Meyer, Warscheid, Sá-Miranda, Azevedo: Members of the E2D (UbcH5) family mediate the ubiquitination of the conserved cysteine of Pex5p, the peroxisomal import receptor. in The Journal of biological chemistry 2008 (PubMed)

More Proteins for Ubiquitin-Conjugating Enzyme E2D 1 Interaction Partners

Human Ubiquitin-Conjugating Enzyme E2D 1 (UBE2D1) interaction partners

  1. The anaphase-promoting complex/cyclosome C activity in human cells is tuned by the combinatorial use of three E2 ubiquitin-conjugating enzymes, namely UBE2C (show UBE2C Proteins), UBE2S (show UBE2S Proteins), and UBE2D.

  2. Data show that ubiquitin E2 enzymes UBE2D1/2/3 and E3 ligase RNF138 (show RNF138 Proteins) accumulate at DNA-damage sites and act at early resection stages by promoting CtIP (show RBBP8 Proteins) protein ubiquitylation and accrual.

  3. The Asp17 mutation in MDM2 stimulated its discharge of the UBCH5a-ubiquitin thioester adduct.

  4. The SMURF2:UBCH5 complex is critical in maintaining KRAS protein stability.

  5. Biochemical characterization of recombinant UBTD1 and UBE2D demonstrated that the two proteins form a stable, stoichiometric complex that can be purified to near homogeneity.

  6. crystal structure of the dimeric RING domain of rat RNF4 in complex with E2 (UbcH5A) linked by an isopeptide bond to ubiquitin

  7. These data demonstrate that the ability of ICP0 to interact with cellular E2 ubiquitin-conjugating enzyme UBE2D1 is fundamentally important for its biological functions during HSV-1 infection.

  8. identify the IDOL (show MYLIP Proteins)-UBE2D complex as an important determinant of LDLR (show LDLR Proteins) activity, and provide insight into molecular mechanisms underlying the regulation of cholesterol uptake

  9. This structure reveals an interaction between the ubiquitin surface flanking K11 and residues adjacent to the E2 catalytic cysteine and suggests a possible role for this surface in formation of K11 linkages.

  10. The authors demonstrate that c-IAP1 (show BIRC2 Proteins) and UbcH5 family promote K11-linked polyubiquitination of receptor-interacting protein 1 (RIP1 (show RIPK1 Proteins)) in vitro and in vivo.

Mouse (Murine) Ubiquitin-Conjugating Enzyme E2D 1 (UBE2D1) interaction partners

  1. Its gene expression is inhibited through p53 (show TP53 Proteins) dependent apoptosis, which is induced by cadmium exposure.(review)

  2. significantly elevated levels of SFT/UbcH5A mRNA in the neonatal mouse and its localization to choroid plexus suggest that this factor may contribute to the rapid rate of brain iron uptake that occurs in the early postnatal period

Ubiquitin-Conjugating Enzyme E2D 1 (UBE2D1) Protein Profile

Protein Summary

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases. Two transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with Ubiquitin-Conjugating Enzyme E2D 1 (UBE2D1)

  • ubiquitin-conjugating enzyme E2D 1 (UBE2D1)
  • ubiquitin-conjugating enzyme E2D 1 (ube2d1)
  • ubiquitin-conjugating enzyme E2D 1 (LOC100341090)
  • ubiquitin-conjugating enzyme E2D 1 (LOC100355225)
  • ubiquitin-conjugating enzyme E2D 1 (Ube2d1)
  • ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast) (UBE2D1)
  • ubiquitin-conjugating enzyme E2D 1b (ube2d1b)
  • E2(17)KB1 protein
  • SFT protein
  • UBC4/5 protein
  • UBCH5 protein
  • UBCH5A protein
  • ube2d1 protein
  • wu:fc16h06 protein
  • zgc:73096 protein

Protein level used designations for UBE2D1

ubiquitin-conjugating enzyme E2 D1 , ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast) , ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog) , ubiquitin-conjugating enzyme E2D 1 , UBC4/5 homolog , stimulator of Fe transport , ubiquitin carrier protein D1 , ubiquitin-conjugating enzyme E2(17)KB 1 , ubiquitin-conjugating enzyme E2-17 kDa 1 , ubiquitin-protein ligase D1 , E2(17)KB 1 , ubiquitin-conjugating enzyme E2D 1, UBC4/5 homolog

701491 Macaca mulatta
745141 Pan troglodytes
780353 Xenopus (Silurana) tropicalis
100341090 Oryctolagus cuniculus
100355225 Oryctolagus cuniculus
495381 Xenopus laevis
7321 Homo sapiens
608578 Canis lupus familiaris
535287 Bos taurus
216080 Mus musculus
361831 Rattus norvegicus
423641 Gallus gallus
324015 Danio rerio
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