Browse our anti-HMGCR (HMGCR) Antibodies

Full name:
anti-3-Hydroxy-3-Methylglutaryl-CoA Reductase Antibodies (HMGCR)
On are 86 3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) Antibodies from 16 different suppliers available. Additionally we are shipping HMGCR Kits (29) and HMGCR Proteins (4) and many more products for this protein. A total of 125 HMGCR products are currently listed.
3H3M, BcDNA:LD15354, bro1, bs32f05.y1, CG10367, clb, Dmel\\CG10367, DmHMG-CoAr, Hmg, hmg-coa-r, HMG-CoAR, hmgc, HMGCoAr, HMGCoARr, hmgcr, HMGCR_Dm, HMGR, hmgrc, l(3)01152, l(3)04684, LDLCQ3, Red
list all antibodies Gene Name GeneID UniProt
HMGCR 3156 P04035
HMGCR 25675 P51639
HMGCR 15357 Q01237

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anti-Human HMGCR Antibodies:

anti-Rat (Rattus) HMGCR Antibodies:

anti-Mouse (Murine) HMGCR Antibodies:

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Top referenced anti-HMGCR Antibodies

  1. Human Polyclonal HMGCR Primary Antibody for IF (p), IHC (p) - ABIN709196 : Wu, He, Wang, Xue, Ning, Zou, Ye, Li, Wang, Pang: The antihypercholesterolemic effect of jatrorrhizine isolated from Rhizoma Coptidis. in Phytomedicine : international journal of phytotherapy and phytopharmacology 2014 (PubMed)
    Show all 4 references for 709196

  2. Human Polyclonal HMGCR Primary Antibody for ICC, IF - ABIN4319308 : Bjarnadottir, Romero, Bendahl, Jirström, Rydén, Loman, Uhlén, Johannesson, Rose, Grabau, Borgquist: Targeting HMG-CoA reductase with statins in a window-of-opportunity breast cancer trial. in Breast cancer research and treatment 2013 (PubMed)
    Show all 4 references for 4319308

More Antibodies against HMGCR Interaction Partners

Fruit Fly (Drosophila melanogaster) 3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) interaction partners

  1. The specificity and evolutionary conservation of the HMGCoAr pathway for germ cells suggest that an attractant common to invertebrates and vertebrates guides germ cells in early embryos.

Human 3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) interaction partners

  1. To estimate the association between changes in levels of LDL-C (and other lipoproteins) and the risk of cardiovascular events related to variants in the CETP (show CETP Antibodies) gene, both alone and in combination with variants in the 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) gene.

  2. Low LDL cholesterol levels due to PCSK9 (show PCSK9 Antibodies) and HMGCR variants had no causal effect on high risk of Alzheimer's disease, vascular dementia, any dementia, or Parkinson's disease; however, low LDL cholesterol levels may have a causal effect in reducing the risk of Alzheimer's disease.

  3. These results indicate that HIF-mediated induction of Insig-2 (show INSIG2 Antibodies) and degradation of HMGCR are physiologically relevant events that guard against wasteful oxygen consumption and inappropriate cell growth during hypoxia.

  4. TGF-beta1 (show TGFB1 Antibodies) induces cholesterol synthesis by increasing HMG-CoA reductase mRNA expression in keratinocytes.

  5. Gene expression profile and the biological functions of HMGCR in gastric cancer were studied. It was found that the expression of HMGCR was increased in gastric cancer tissues. Over-expression of HMGCR promoted the growth and migration of gastric cancer cells, while knocking down the expression of HMGCR inhibited the growth, migration and tumorigenesis of gastric cancer cells.

  6. In this study, variants in PCSK9 (show PCSK9 Antibodies) had approximately the same effect as variants in HMGCR on the risk of cardiovascular events and diabetes per unit decrease in the LDL cholesterol level. The effects of these variants were independent and additive.

  7. Data show that simvastatin significantly inhibited cellular proliferation, induced cell cycle G1 arrest and apoptosis, and caused cellular stress via reduction in the enzymatic activity of 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMGCR).

  8. no associations found between HMGCR rs3846662, HMRCR alternative splicing and Alzheimer's disease pathology pathology.

  9. results indicate that abnormal lipid metabolism may exist in spontaneous preterm delivery (SPTD) women and the premature fetus and the HMGCR gene may be a susceptible gene for SPTD

  10. Report the mechanism of polyphenol binding to and activity regulation of HMGR (show HMGA1 Antibodies) using molecular docking.

Pig (Porcine) 3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) interaction partners

  1. The relative expression level of HMGR was high in liver, heart, kidney, bladder and subcutaneous fat, medium in lung, uterus and large intestine, and low in cerebrum, spleen, spinal cord, stomach, ovary, longissimus muscle, and small intestine.

Mouse (Murine) 3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) interaction partners

  1. These results indicate that HIF-mediated induction of Insig-2 (show INSIG2 Antibodies) and degradation of HMGCR are physiologically relevant events that guard against wasteful oxygen consumption and inappropriate cell growth during hypoxia.

  2. these studies designate sterol-accelerated degradation of HMGCR as a potential therapeutic target for prevention of atherosclerosis and associated cardiovascular disease.

  3. To eludicate the mechanisms underlying statin myotoxicity and HMGCR function in skeletal muscle, we developed the skeletal muscle-specific (show EIF3K Antibodies) HMGCR knockout mice.

  4. High-dose simvastatin inhibits HMGCoA reductase and prevents experimental hyperinflation lung injury by angioprotective and anti-inflammatory effects.

  5. TSH can regulate the phosphorylation of HMGCR via AMPK (show PRKAA1 Antibodies).

  6. HMGCR proteasomal-degradation by IFN strictly requires the synthesis of endogenous 25-Hydroxycholesterol.

  7. Increased cholesterol synthesis mediated by HMGCoA (show HMGCS2 Antibodies)-R under inflammatory stress may be one of the mechanisms for intracellular lipid accumulation and statin resistance.

  8. we consistently observe involvement of gp78 (show AMFR Antibodies) in Insig-1 (show INSIG1 Antibodies) degradation, we find no substantive evidence to support roles for either gp78 (show AMFR Antibodies) or TRC8 (show RNF139 Antibodies) in the robust sterol-accelerated degradation of HMG-CoA reductase.

  9. Hepatocyte HMGCR is essential for the survival of mice, and its abrogation elicits hepatic steatosis with jaundice and hypoglycemia.

  10. Linalool reduces the expression of 3-hydroxy-3-methylglutaryl CoA reductase via sterol regulatory element binding protein-2- and ubiquitin-dependent mechanisms.

HMGCR Antigen Profile

Antigen Summary

HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with HMGCR

  • HMG Coenzyme A reductase (Hmgcr) antibody
  • 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) antibody
  • 3-hydroxy-3-methylglutaryl-CoA reductase (Hmgcr) antibody
  • 3-hydroxy-3-methylglutaryl-CoA reductase (hmgcr) antibody
  • 3-hydroxy-3-methylglutaryl-Coenzyme A reductase (Hmgcr) antibody
  • 3-hydroxy-3-methylglutaryl-Coenzyme A reductase (LOC100357791) antibody
  • 3H3M antibody
  • BcDNA:LD15354 antibody
  • bro1 antibody
  • bs32f05.y1 antibody
  • CG10367 antibody
  • clb antibody
  • Dmel\\CG10367 antibody
  • DmHMG-CoAr antibody
  • Hmg antibody
  • hmg-coa-r antibody
  • HMG-CoAR antibody
  • hmgc antibody
  • HMGCoAr antibody
  • HMGCoARr antibody
  • hmgcr antibody
  • HMGCR_Dm antibody
  • HMGR antibody
  • hmgrc antibody
  • l(3)01152 antibody
  • l(3)04684 antibody
  • LDLCQ3 antibody
  • Red antibody

Protein level used designations for HMGCR

3-Hydroxy-3-Methylglutaryl CoA reductase , 3-hydroxy-3-methylglutaryl coenzyme A reductase , CG10367-PA , HMG coenzyme A reductase , HMG-CoA reductase , HMGCo-A reductase , HMGCoA reductase , Hmg-CoA-reductase , Hmgcr-PA , columbus , lethal (3) 04684 , 3-hydroxy-3-methylglutaryl CoA reductase (NADPH) , 3-hydroxy-3-methylglutaryl-Coenzyme A reductase , hydroxymethylglutaryl-CoA reductase , 3-hydroxy-3-methylglutaryl coenzyme A reductase/HMG-CoA reductase , 3-hydroxy-3-methylglutaryl-coenzyme A reductase , 3-hydroxy-3-methylglutaryl CoA reductase , 3-hydroxy-3-methylglutaryl-CoA reductase

42803 Drosophila melanogaster
3156 Homo sapiens
479182 Canis lupus familiaris
100144446 Sus scrofa
407159 Bos taurus
25675 Rattus norvegicus
395145 Gallus gallus
397750 Xenopus laevis
100173499 Pongo abelii
15357 Mus musculus
100357791 Oryctolagus cuniculus
100756363 Cricetulus griseus
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