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Browse our HMGCR Proteins (HMGCR)

Full name:
3-Hydroxy-3-Methylglutaryl-CoA Reductase Proteins (HMGCR)
On www.antibodies-online.com are 4 3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) Proteins from 3 different suppliers available. Additionally we are shipping HMGCR Antibodies (80) and HMGCR Kits (25) and many more products for this protein. A total of 114 HMGCR products are currently listed.
Synonyms:
3H3M, BcDNA:LD15354, bro1, bs32f05.y1, CG10367, clb, Dmel\\CG10367, DmHMG-CoAr, Hmg, hmg-coa-r, HMG-CoAR, hmgc, HMGCoAr, HMGCoARr, hmgcr, HMGCR_Dm, HMGR, hmgrc, l(3)01152, l(3)04684, LDLCQ3, Red
list all proteins Gene Name GeneID UniProt
HMGCR 3156 P04035
Rat HMGCR HMGCR 25675 P51639
HMGCR 15357 Q01237

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HMGCR Proteins (HMGCR) by Origin

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More Proteins for HMGCR Interaction Partners

Fruit Fly (Drosophila melanogaster) 3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) interaction partners

  1. The specificity and evolutionary conservation of the HMGCoAr pathway for germ cells suggest that an attractant common to invertebrates and vertebrates guides germ cells in early embryos.

Human 3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) interaction partners

  1. TGF-beta1 (show TGFB1 Proteins) induces cholesterol synthesis by increasing HMG-CoA reductase mRNA expression in keratinocytes.

  2. Gene expression profile and the biological functions of HMGCR in gastric cancer were studied. It was found that the expression of HMGCR was increased in gastric cancer tissues. Over-expression of HMGCR promoted the growth and migration of gastric cancer cells, while knocking down the expression of HMGCR inhibited the growth, migration and tumorigenesis of gastric cancer cells.

  3. In this study, variants in PCSK9 (show PCSK9 Proteins) had approximately the same effect as variants in HMGCR on the risk of cardiovascular events and diabetes per unit decrease in the LDL cholesterol level. The effects of these variants were independent and additive.

  4. Data show that simvastatin significantly inhibited cellular proliferation, induced cell cycle G1 arrest and apoptosis, and caused cellular stress via reduction in the enzymatic activity of 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMGCR).

  5. no associations found between HMGCR rs3846662, HMRCR alternative splicing and Alzheimer's disease pathology pathology.

  6. results indicate that abnormal lipid metabolism may exist in spontaneous preterm delivery (SPTD) women and the premature fetus and the HMGCR gene may be a susceptible gene for SPTD

  7. Report the mechanism of polyphenol binding to and activity regulation of HMGR (show HMGA1 Proteins) using molecular docking.

  8. the results of the present study showed that luteolin modulates HMGCR transcription by decreasing the expression and nuclear translocation of SREBP-2 (show SREBF2 Proteins).

  9. Discovery new drug candidates for inhibition of human HMG-CoA reductase through structure-based virtual screening.

  10. Results show that HMGCR rs3846662 acts as a potent genetic modifier for Alzheimer's disease risk, age of onset and conversion from mild cognitively impairment

Pig (Porcine) 3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) interaction partners

  1. The relative expression level of HMGR was high in liver, heart, kidney, bladder and subcutaneous fat, medium in lung, uterus and large intestine, and low in cerebrum, spleen, spinal cord, stomach, ovary, longissimus muscle, and small intestine.

Mouse (Murine) 3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) interaction partners

  1. these studies designate sterol-accelerated degradation of HMGCR as a potential therapeutic target for prevention of atherosclerosis and associated cardiovascular disease.

  2. To eludicate the mechanisms underlying statin myotoxicity and HMGCR function in skeletal muscle, we developed the skeletal muscle-specific (show EIF3K Proteins) HMGCR knockout mice.

  3. High-dose simvastatin inhibits HMGCoA reductase and prevents experimental hyperinflation lung injury by angioprotective and anti-inflammatory effects.

  4. TSH can regulate the phosphorylation of HMGCR via AMPK (show PRKAA1 Proteins).

  5. HMGCR proteasomal-degradation by IFN strictly requires the synthesis of endogenous 25-Hydroxycholesterol.

  6. Increased cholesterol synthesis mediated by HMGCoA (show HMGCS2 Proteins)-R under inflammatory stress may be one of the mechanisms for intracellular lipid accumulation and statin resistance.

  7. we consistently observe involvement of gp78 (show AMFR Proteins) in Insig-1 degradation, we find no substantive evidence to support roles for either gp78 (show AMFR Proteins) or TRC8 (show RNF139 Proteins) in the robust sterol-accelerated degradation of HMG-CoA reductase.

  8. Hepatocyte HMGCR is essential for the survival of mice, and its abrogation elicits hepatic steatosis with jaundice and hypoglycemia.

  9. Linalool reduces the expression of 3-hydroxy-3-methylglutaryl CoA reductase via sterol regulatory element binding protein-2- and ubiquitin-dependent mechanisms.

  10. Although gene expressions of HMG-CoAR and CYP7A1 (show CYP7A1 Proteins) in diabetic buckwheat sprout-fed groups were higher than in the diabetic control group, the elevation of mRNA level of CYP7A1 (show CYP7A1 Proteins) was greater than that of HMG-CoAR.

HMGCR Protein Profile

Protein Summary

HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with HMGCR

  • HMG Coenzyme A reductase (Hmgcr)
  • 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR)
  • 3-hydroxy-3-methylglutaryl-CoA reductase (Hmgcr)
  • 3-hydroxy-3-methylglutaryl-CoA reductase (hmgcr)
  • 3-hydroxy-3-methylglutaryl-Coenzyme A reductase (Hmgcr)
  • 3-hydroxy-3-methylglutaryl-Coenzyme A reductase (LOC100357791)
  • 3H3M protein
  • BcDNA:LD15354 protein
  • bro1 protein
  • bs32f05.y1 protein
  • CG10367 protein
  • clb protein
  • Dmel\\CG10367 protein
  • DmHMG-CoAr protein
  • Hmg protein
  • hmg-coa-r protein
  • HMG-CoAR protein
  • hmgc protein
  • HMGCoAr protein
  • HMGCoARr protein
  • hmgcr protein
  • HMGCR_Dm protein
  • HMGR protein
  • hmgrc protein
  • l(3)01152 protein
  • l(3)04684 protein
  • LDLCQ3 protein
  • Red protein

Protein level used designations for HMGCR

3-Hydroxy-3-Methylglutaryl CoA reductase , 3-hydroxy-3-methylglutaryl coenzyme A reductase , CG10367-PA , HMG coenzyme A reductase , HMG-CoA reductase , HMGCo-A reductase , HMGCoA reductase , Hmg-CoA-reductase , Hmgcr-PA , columbus , lethal (3) 04684 , 3-hydroxy-3-methylglutaryl CoA reductase (NADPH) , 3-hydroxy-3-methylglutaryl-Coenzyme A reductase , hydroxymethylglutaryl-CoA reductase , 3-hydroxy-3-methylglutaryl coenzyme A reductase/HMG-CoA reductase , 3-hydroxy-3-methylglutaryl-coenzyme A reductase , 3-hydroxy-3-methylglutaryl CoA reductase , 3-hydroxy-3-methylglutaryl-CoA reductase

GENE ID SPECIES
42803 Drosophila melanogaster
3156 Homo sapiens
479182 Canis lupus familiaris
100144446 Sus scrofa
407159 Bos taurus
25675 Rattus norvegicus
395145 Gallus gallus
397750 Xenopus laevis
100173499 Pongo abelii
15357 Mus musculus
100357791 Oryctolagus cuniculus
100756363 Cricetulus griseus
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