Thrombomodulin antibody

Catalog No. ABIN1105877

Product Details anti-Thrombomodulin Antibody

Target: Thrombomodulin (THBD)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Thrombomodulin antibody is un-conjugated

Application: Flow Cytometry (FACS)

Specificity: Recognises the soluble antigen. Recognises Thrombomodulin (TM), a 105 kDa protein.

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Ion Exchange Chromatography

Sterility: 0.22 μm filtered

Immunogen: TF1 cell line.

Clone: B-A35

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS, Sterile-filtered through 0.22 μm, Carrier and preservative free

Preservative: Without preservative

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.

Target Details for Thrombomodulin

Target: Thrombomodulin (THBD)

Alternative Name: CD141 / THBD (THBD Products)

Background: CD141/Thrombomodulin is an exclusively endothelial cell surface glycoprotein that forms a 1:1 complex with thrombin. Binding of thrombin to this high-affinity receptor alters its specificity toward several substrates. The complex activates protein C approximately 1000 times faster than thrombin alone. Activated protein C degrades clotting factors V and VIII, thus, thrombomodulin converts thrombin into a physiologic anticoagulant. Thrombomodulin is also found in the circulatory and urinary systems, the physiologic significance of this is obscure.Synonyms: Fetomodulin, THRM, Thrombomodulin

Gene ID: 7056

NCBI Accession: NP_000352

UniProt: P07204