C-C Chemokine Receptor Type 1 (CCR1) antibody (PE)

Details for Product No. ABIN1105988
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Antigen
Synonyms CD191, CKR-1, CKR1, CMKBR1, HM145, MIP1aR, SCYAR1, Cmkbr1, Mip-1a-R
Reactivity
Human
(54), (22), (14), (2), (1)
Host
Mouse
(44), (6), (4), (4), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
PE
(3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Flow Cytometry (FACS)
(35), (18), (18), (18), (10), (10), (5), (3), (2), (1)
Pubmed 12 references available
Quantity 50 tests
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
Request Want additional data for this product?

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Catalog No. ABIN1105988
368.50 $
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Immunogen Human PBMC (peripheral blood mononuclear cell) CCR-1
Clone 141-2
Isotype IgG1
Specificity This antibody reacts with CCR1.
Purification Protein-A Sepharose
Alternative Name CD191 / CCR1
Background Chemokines, which are a group of 70 to 90 amino acid structurally-related polypeptides, were first isolated as the regulation factors of leukocyte recirculation and “homing in” inflammatory and immunological responses. Several studies have shown that chemokines are also crucially involved in other physiological and pathogenic processes, including hematopoiesis, angiogenesis, allergy, autoimmune diseases, and viral infectious diseases. There are two major groups in the chemokine super family, the CXC subfamily, in which the N-terminal two cysteines (of the four well-conserved cysteines common to the chemokine superfamily) are separated by a single amino acid, and the CC subfamily, in which they are adjacent. Other subfamilies are designated as the C subfamily and the CX3C subfamily. CCR1 is a G-protein-coupled seven-transmembrane receptor, to which CC chemokines bind specifically. It is expressed on the cell surface of various types of blood cells, including monocytes, acidophils, basophils, and T cells.
Alternate names: C-C CKR-1, C-C chemokine receptor type 1, CC-CKR-1, CCR-1, CMKBR1, CMKR1, HM145, LD78 receptor, MIP1 alpha Receptor, Macrophage inflammatory protein 1-alpha receptor, RANTES- R, SCYAR1
Gene ID 1230
NCBI Accession NP_001286
UniProt P32246
Research Area Chemokines, Receptors
Restrictions For Research Use only
Format Liquid
Concentration 10 µg/mL
Buffer PBS, 0.09% Sodium azide, 1% BSA
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store at 2 - 8 °C.
Expiry Date 12 months
Supplier Images
anti-C-C Chemokine Receptor Type 1 (CCR1) antibody (PE) anti-C-C Chemokine Receptor Type 1 (CCR1) antibody (PE)
Background publications Miller, Krangel: "Biology and biochemistry of the chemokines: a family of chemotactic and inflammatory cytokines." in: Critical reviews in immunology, Vol. 12, Issue 1-2, pp. 17-46, 1992 (PubMed).

Oppenheim, Zachariae, Mukaida et al.: "Properties of the novel proinflammatory supergene \intercrine\" cytokine family."" in: Annual review of immunology, Vol. 9, pp. 617-48, 1991 (PubMed).

Kelner, Kennedy, Bacon et al.: "Lymphotactin: a cytokine that represents a new class of chemokine." in: Science (New York, N.Y.), Vol. 266, Issue 5189, pp. 1395-9, 1994 (PubMed).

Baggiolini, Dewald, Moser: "Interleukin-8 and related chemotactic cytokines--CXC and CC chemokines." in: Advances in immunology, Vol. 55, pp. 97-179, 1994 (PubMed).

Curtis: "Defending attacks on statistics." in: Nature medicine, Vol. 2, Issue 1, pp. 4-5, 1996 (PubMed).

Rollins: "Chemokines." in: Blood, Vol. 90, Issue 3, pp. 909-28, 1997 (PubMed).

Sato, Kawasaki, Nagayama et al.: "Signaling events following chemokine receptor ligation in human dendritic cells at different developmental stages." in: International immunology, Vol. 13, Issue 2, pp. 167-79, 2001 (PubMed).

Sato, Kawasaki, Nagayama et al.: "Chemokine receptor expressions and responsiveness of cord blood T cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 166, Issue 3, pp. 1659-66, 2001 (PubMed).

Sato, Kawasaki, Morimoto et al.: "An abortive ligand-induced activation of CCR1-mediated downstream signaling event and a deficiency of CCR5 expression are associated with the hyporesponsiveness of human naive CD4+ T cells to CCL3 and CCL5." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 168, Issue 12, pp. 6263-72, 2002 (PubMed).

Sato, Higuchi, Yoshioka et al.: "Trophoblasts acquire a chemokine receptor, CCR1, as they differentiate towards invasive phenotype." in: Development (Cambridge, England), Vol. 130, Issue 22, pp. 5519-32, 2003 (PubMed).

Sato, Fujiwara, Zeng et al.: "Platelet-derived soluble factors induce human extravillous trophoblast migration and differentiation: platelets are a possible regulator of trophoblast infiltration into maternal spiral arteries." in: Blood, Vol. 106, Issue 2, pp. 428-35, 2005 (PubMed).

Rosen: "Homing in on L-selectin." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 177, Issue 1, pp. 3-4, 2006 (PubMed).

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