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Toll-Like Receptor 1 (TLR1) antibody (Biotin)

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Synonyms CD281, TIL, TIL. LPRS5, rsc786
(163), (72), (26)
(126), (47), (11), (5)
Clonality (Clone)
Monoclonal ()
(14), (14), (14), (4), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro)), Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(114), (61), (57), (51), (32), (17), (17), (13), (11), (7), (7), (6), (2), (1), (1)
Pubmed 7 references available
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Quantity 50 μg
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Immunogen TLR1Fc
Clone GD2-F4
Isotype IgG1
Cross-Reactivity (Details) Species reactivity (tested):Human
Purification Protein G
Alternative Name CD281 / TLR1 (TLR1 Antibody Abstract)
Background Toll-like receptors (TLR) are highly conserved throughout evolution and play an essential role in recognizing conserved motifs found in various pathogens and initiating an appropriate innate immune response. In human, ten members of the TLR family have been identified as type I transmembrane signaling receptors containing multiple copies of leucine rich repeats in the extracellular domain and an interleukin-1 (IL-1) receptor motif in the cytoplasmic domain. Mammalian responsiveness to microbial products may be mediated by combinations of TLRs, for example a co-operative effect is observed between TLR1 and TLR2 in response to bacterial lipoproteins. On the other hand, TLR 1 was shown to have the capacity to abrogate TLR4 signaling. In general, TLR1 is expressed at higher levels as compared to other TLRs. The highest expression of TLR1 is found in monocytes but it can also be expressed by macrophages, dendritic cells, B, T, and NK cells. In recent studies, several human TLR1 polymorphisms have been associated with impaired mycobacterial signaling and susceptibility to tuberculosis.Synonyms: KIAA0012, TIL, Toll-like receptor 1, Toll/interleukin-1 receptor-like protein
Gene ID 9606
UniProt Q15399
Research Area Signaling, Immunology, Inflammation
Pathways TLR Signaling
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 0.1 mg/mL
Buffer PBS, 0.1 % bovine serum albumin
Storage 4 °C
Storage Comment Store at 2 - 8 °C.
Background publications Panda, Qian, Mohanty et al.: "Age-associated decrease in TLR function in primary human dendritic cells predicts influenza vaccine response." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 184, Issue 5, pp. 2518-27, 2010 (PubMed).

Zhou, Danilov, Notten: "A novel method for the in situ determination of concentration gradients in the electrolyte of Li-ion batteries." in: Chemistry (Weinheim an der Bergstrasse, Germany), Vol. 12, Issue 27, pp. 7125-32, 2006 (PubMed).

Månsson, Adner, Höckerfelt et al.: "A distinct Toll-like receptor repertoire in human tonsillar B cells, directly activated by PamCSK, R-837 and CpG-2006 stimulation." in: Immunology, Vol. 118, Issue 4, pp. 539-48, 2006 (PubMed).

Sandor, Latz, Re et al.: "Importance of extra- and intracellular domains of TLR1 and TLR2 in NFkappa B signaling." in: The Journal of cell biology, Vol. 162, Issue 6, pp. 1099-110, 2003 (PubMed).

Ochoa, Legaspi, Hatziris et al.: "Distribution of Toll-like receptor 1 and Toll-like receptor 2 in human lymphoid tissue." in: Immunology, Vol. 108, Issue 1, pp. 10-5, 2003 (PubMed).

Visintin, Mazzoni, Spitzer et al.: "Regulation of Toll-like receptors in human monocytes and dendritic cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 166, Issue 1, pp. 249-55, 2001 (PubMed).

Wyllie, Kiss-Toth, Visintin et al.: "Evidence for an accessory protein function for Toll-like receptor 1 in anti-bacterial responses." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 165, Issue 12, pp. 7125-32, 2000 (PubMed).

Catalog No. ABIN1106187
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