Fms-Related tyrosine Kinase 1 (Vascular Endothelial Growth Factor/vascular Permeability Factor Receptor) (FLT1) (C-Term) antibody

Details for Product No. ABIN115390
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Antigen
Synonyms FLT1, VEGFR1, AI323757, Flt-1, VEGFR-1, sFlt1, FLT, FLT-1, flt1b
Epitope
C-Term
(29), (14), (13), (10), (10), (7), (6), (4), (4), (4), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(213), (70), (60), (6), (2), (2), (1)
Host
Rabbit
(164), (62), (6), (5), (2), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(11), (7), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(143), (121), (58), (48), (41), (23), (22), (20), (18), (10), (4), (2), (2), (1), (1), (1)
Pubmed 2 references available
Quantity 1 mL
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Catalog No. ABIN115390
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Immunogen A synthetic peptide derived from the C-terminus of the Flt-1 precursor of human origin
Specificity This antibody reacts with a 180 kD protein, known as Flt-1/Vascular Endothelial Growth Factor Receptor 1. Cellular localization: cytoplasmic.
Purification Purified
Alternative Name VEGFR-1 / Flt-1
Background VEGF Receptor 1 (also known as FLT) belongs to the src gene family and shows tyrosine protein kinase activity that is important for the control of cell proliferation and differentiation. The protein acts as a receptor for VEGF, VEGFB and PGF. An alternatively spliced form of the gene produces a soluble protein (sFlt1) which binds vascular endothelial growth factor (VEGF) with high affinity. sFlt1 has a higher affinity for VEGF indicating that it may function as an inhibitor in the VEGF response. VEGF Receptor 1 is specifically expressed in most vascular endothelial cells and peripheral blood monocytes. Flt-1 is a cell membrane receptor kinase. Flk-1 has a high affinity receptor for vascular endothelial growth factor and is putatively involved in the growth of endothelial cells and angiogenesis.
Alternate names: FLT, FLT1, FRT, Fms-like tyrosine kinase 1, Tyrosine-protein kinase FRT, Tyrosine-protein kinase receptor FLT, VEGF Receptor 1, VEGFR1, Vascular endothelial growth factor receptor 1, Vascular permeability factor receptor
Gene ID 2321
NCBI Accession NP_001153392
UniProt P17948
Research Area Cytokines, Receptors
Application Notes Immunohistochemistry on Formalin-Fixed Paraffin Embedded Tissues: Use a dilution of1/50-1/100 in an ABC method (incubation period of 30 minutes at room temperature). Formalin fixed paraffin embedded tissue sections require high temperature antigenunmasking with 10 mM citrate buffer, pH 6.0, prior to immunostaining. Recommended Positive Control: Angiosarcoma. Also useful for Western blotting. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8°C.
Expiry Date 12 months
Supplier Images
anti-Fms-Related tyrosine Kinase 1 (Vascular Endothelial Growth Factor/vascular Permeability Factor Receptor) (FLT1) (C-Term) antibody Formalin fixed paraffin embedded human angiosarcoma stained with Flt-1 antibody
General Sato, Takino, Okada et al.: "A matrix metalloproteinase expressed on the surface of invasive tumour cells." in: Nature, Vol. 370, Issue 6484, pp. 61-5, 1994 (PubMed).

Sato, Kinoshita, Takino et al.: "Activation of a recombinant membrane type 1-matrix metalloproteinase (MT1-MMP) by furin and its interaction with tissue inhibitor of metalloproteinases (TIMP)-2." in: FEBS letters, Vol. 393, Issue 1, pp. 101-4, 1996 (PubMed).

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