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Integrin beta 1 (ITGB1) antibody

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Synonyms cd29, fnrb, gpiia, itgb1, mdf2, msk12, vla-beta, vlab, CD29, 4633401G24Rik, AA409975, AA960159, ENSMUSG00000051907, Fnrb, Gm9863, gpIIa, FNRB, GPIIA, MDF2, MSK12, VLA-BETA, VLAB
Human, Monkey
(434), (181), (133), (27), (20), (9), (8), (7), (7), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1)
(294), (162), (84), (16), (11), (3), (1)
Clonality (Clone)
Monoclonal ()
(64), (56), (37), (18), (8), (7), (6), (4), (4), (3), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Enzyme Immunoassay (EIA), Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Western Blotting (WB)
(334), (256), (136), (116), (88), (66), (53), (38), (19), (15), (11), (8), (7), (6), (6), (4), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1)
Pubmed 7 references available
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Quantity 0.2 mg
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Immunogen Purified Human beta-1 integrin. Remarks: Spleen cells from immunised BALB/c mice were fused with cells of the NS1 mouse myeloma cell line.
Clone JB1B
Isotype IgG2a
Purification Ammonium Sulphate Precipitation
Alternative Name CD29 / Integrin beta-1 (ITGB1 Antibody Abstract)
Background Integrin beta 1, also known as CD29, is a 130 kDa transmembrane glycoprotein that forms noncovalent complexes with various Integrin alpha subunits (including alpha 1, alpha 2, alpha 3, alpha 4, alpha 5, and alpha 6, also known as CD49a, CD49b, CD49c, CD49d, CD49e, and CD49f, respectively) to form the functional receptors that bind to specific extracellular matrix proteins. Integrin receptors are involved in the regulation of a variety of important biological functions, including embryonic development, wound repair, hemostasis, and prevention of programmed cell death. They are also implicated in abnormal pathological states such as tumor directed angiogenesis, tumor cell growth, and metastasis. These heterodimeric receptors bridge the cytoplasmic actin cytoskeleton with proteins present in the extracellular matrix and/or on adjacent cells. The clustering of integrins on a cell surface leads to the formation of focal contacts. Interactions between integrins and the extracellular matrix lead to activation of signal transduction pathways and regulation of gene expression. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.Synonyms: FNRB, Fibronectin receptor subunit beta, ITGB1, Integrin VLA-4 subunit beta, MDF2, MSK12
Gene ID 9606
UniProt P05556
Research Area CD Antigens, Surface Receptors of Immune Cells
Application Notes Flow cytometry: 1 μg/10^6cells. Immunoprecipitation: 1 - 5 μg/mL. Immunohistochemistry on frozen sections: 5 μg/mL. ELISA: 0.1-1 μg/mL. Western Blot.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer PBS, 0.09 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Product cited in: Haglund, Tillgren, Addis et al.: "Identification and characterization of the integrin alpha2beta1 binding motif in chondroadherin mediating cell attachment." in: The Journal of biological chemistry, Vol. 286, Issue 5, pp. 3925-34, 2011 (PubMed).

Background publications Batista da Silva, Lee, Bajenova et al.: "The major outer sheath protein of Treponema denticola inhibits the binding step of collagen phagocytosis in fibroblasts." in: Cellular microbiology, Vol. 6, Issue 5, pp. 485-98, 2004 (PubMed).

Stroomer, Roos, Sproll et al.: "Safety and biodistribution of 99mTechnetium-labeled anti-CD44v6 monoclonal antibody BIWA 1 in head and neck cancer patients." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 6, Issue 8, pp. 3046-55, 2000 (PubMed).

Yoshino, Ami, Terao et al.: "Upgrading of flow cytometric analysis for absolute counts, cytokines and other antigenic molecules of cynomolgus monkeys (Macaca fascicularis) by using anti-human cross-reactive antibodies." in: Experimental animals / Japanese Association for Laboratory Animal Science, Vol. 49, Issue 2, pp. 97-110, 2000 (PubMed).

Levite, Cahalon, Peretz et al.: "Extracellular K(+) and opening of voltage-gated potassium channels activate T cell integrin function: physical and functional association between Kv1.3 channels and beta1 integrins." in: The Journal of experimental medicine, Vol. 191, Issue 7, pp. 1167-76, 2000 (PubMed).

Wilkins, Li, Ni et al.: "Control of beta1 integrin function. Localization of stimulatory epitopes." in: The Journal of biological chemistry, Vol. 271, Issue 6, pp. 3046-51, 1996 (PubMed).

Stupack, Shen, Wilkins: "Control of lymphocyte integrin function: evidence for multiple contributing factors." in: Cellular immunology, Vol. 155, Issue 1, pp. 237-45, 1994 (PubMed).

Catalog No. ABIN120030
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