ITGB1 antibody (AA 25-100)

Catalog No. ABIN669216

Product Details anti-ITGB1 Antibody

Target: ITGB1 (Integrin beta 1 (ITGB1))

Binding Specificity: AA 25-100

Reactivity: Human, Mouse, Rat, Sheep, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ITGB1 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Cross-Reactivity: Human, Mouse, Rabbit, Rat, Sheep

Predicted Reactivity: Dog,Cow,Pig,Horse,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Integrin beta 1

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-ITGB1 antibody (ABIN669216)

Ji, Zhang, Zhang, Fan, Liu, Yang, Hu, Liu, Dong: "MicroRNA 143-5p regulates alpaca melanocyte migration, proliferation and melanogenesis." in: Experimental dermatology, Vol. 27, Issue 2, pp. 166-171, (2018) (PubMed).

Zhao, Yu, Yang, Xue, Liu, Jin: "Knockdown of Snail inhibits epithelial-mesenchymal transition of human laryngeal squamous cell carcinoma Hep-2 cells through the vitamin D receptor signaling pathway." in: Biochemistry and cell biology = Biochimie et biologie cellulaire, Vol. 95, Issue 6, pp. 672-678, (2017) (PubMed).

Qin, Wang, Zheng, Zhou, Zhang, Yang, Zhou: "Concentrated growth factor promotes Schwann cell migration partly through the integrin β1-mediated activation of the focal adhesion kinase pathway." in: International journal of molecular medicine, Vol. 37, Issue 5, pp. 1363-70, (2016) (PubMed).

Wang, Huang, Tang, Lin, Zhou: "Effects of panax notoginseng saponins on the osteogenic differentiation of rabbit bone mesenchymal stem cells through TGF-β1 signaling pathway." in: BMC complementary and alternative medicine, Vol. 16, Issue 1, pp. 319, (2016) (PubMed).

Oralova, Matalova, Killinger, Knopfova, Smarda, Buchtova: "Osteogenic Potential of the Transcription Factor c-MYB." in: Calcified tissue international, Vol. 100, Issue 3, pp. 311-322, (2016) (PubMed).

Fu, Song, Wen, Lu, Cui: "Inositol Hexaphosphate and Inositol Inhibit Colorectal Cancer Metastasis to the Liver in BALB/c Mice." in: Nutrients, Vol. 8, Issue 5, (2016) (PubMed).

Deng, Chen, Li, Yuan, Li, Ke, Wang, Wu, Luo: "Bone marrow mesenchymal stromal cells with CD47 high expression via the signal transducer and activators of transcription signaling pathway preventing myocardial fibrosis." in: International journal of clinical and experimental pathology, Vol. 8, Issue 9, pp. 10555-64, (2015) (PubMed).

Jiang, Wang, Zhang, Tang, Ren, Chen: "The role of CD29-ILK-Akt signaling-mediated epithelial-mesenchymal transition of liver epithelial cells and chemoresistance and radioresistance in hepatocellular carcinoma cells." in: Medical oncology (Northwood, London, England), Vol. 32, Issue 5, pp. 141, (2015) (PubMed).

Lei, Guo, Qiu, Lai, Yang, Widelitz, Chuong, Lian, Yang: "Modulating hair follicle size with Wnt10b/DKK1 during hair regeneration." in: Experimental dermatology, Vol. 23, Issue 6, pp. 407-13, (2014) (PubMed).

Chen, Shi, Shu, Xie, Yang, Zhang, Ruan, Lin, Lin, Shen, Zhang, Feng, Xie: "The effect of porcine ADM to improve the burn wound healing." in: International journal of clinical and experimental pathology, Vol. 6, Issue 11, pp. 2280-91, (2013) (PubMed).

Target Details for ITGB1

Target: ITGB1 (Integrin beta 1 (ITGB1))

Alternative Name: Integrin beta 1 (ITGB1 Products)

Synonyms: CD29 antibody, FNRB antibody, GPIIA antibody, MDF2 antibody, MSK12 antibody, VLA-BETA antibody, VLAB antibody, 4633401G24Rik antibody, AA409975 antibody, AA960159 antibody, ENSMUSG00000051907 antibody, Fnrb antibody, Gm9863 antibody, gpIIa antibody, cd29 antibody, fnrb antibody, gpiia antibody, itgb1 antibody, mdf2 antibody, msk12 antibody, vla-beta antibody, vlab antibody, itgb1-a antibody, itgb1-b antibody, integrin subunit beta 1 antibody, integrin beta 1 (fibronectin receptor beta) antibody, integrin subunit beta 1 S homeolog antibody, integrin beta 1 antibody, integrin subunit beta 1 L homeolog antibody, ITGB1 antibody, Itgb1 antibody, itgb1.S antibody, LOC100009173 antibody, itgb1.L antibody

Background:

Synonyms: CD29, FNRB, MDF2, VLAB, GPIIA, MSK12, VLA-BETA, Integrin beta-1, Fibronectin receptor subunit beta, Glycoprotein IIa, VLA-4 subunit beta, ITGB1

Background: Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. Isoform beta-1B interferes with isoform beta-1A resulting in a dominant negative effect on cell adhesion and migration (in vitro). In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.

Gene ID: 3688

UniProt: P05556

Pathways: Cell-Cell Junction Organization, Regulation of G-Protein Coupled Receptor Protein Signaling, CXCR4-mediated Signaling Events, Signaling of Hepatocyte Growth Factor Receptor, Integrin Complex, SARS-CoV-2 Protein Interactome