Caspase 1 (CASP1) (C-Term) antibody

Details for Product No. ABIN121891
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Antigen
Synonyms CG5370, DCP-1, DCP1, Dcp1, Dmel\\CG5370, ccp1, dcp-1, dcp1, l(2)01862, l(2)02132, Ice, ICE, Il1bc, IL1BC, P45, CASP1
Epitope
C-Term
(31), (15), (8), (8), (6), (5), (5), (4), (4), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(147), (49), (43), (5), (4), (1), (1), (1), (1), (1)
Host
Rabbit
(156), (6), (4), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(10), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(139), (90), (63), (56), (18), (14), (14), (12), (10), (3), (1), (1)
Pubmed 4 references available
Quantity 0.1 mg
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
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Catalog No. ABIN121891
643.50 $
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Immunogen A 16 amino acid peptide located near human Caspase-1 carboxy terminus
Purification Affinity chromatography
Alternative Name Caspase-1
Background Caspase-1 is an intracellular cysteine protease, identified as a mammalian homologue to C. elegans cell death gene (ced-3). Caspase-1 has been classified as an inflammatory, rather than apoptotic caspase, due to its essential role in the cleavage of the inactive precursors of the cytokines IL-1beta and IL-18, into their mature activated and secretable forms. This regulation of pro-inflammatory cytokines by Caspase-1 has made inhibitors of Caspase-1 a possible target for use as therapeutic drugs for the treatment of inflammatory diseases. Alternate Names: CASP1, ICE, p45, IL-1BC, IL1BC, IL1BCE, Caspase 1, Caspase1, CASP 1, Interleukin-1 beta convertase, Interleukin-1 beta-converting enzyme, IL-1 beta-converting enzyme.
UniProt P29466
Research Area Apoptosis/Necrosis
Application Notes Western Blot: 0.5ug - 1.0ug/ml. Immunohistochemistry on paraffin sections: 0.5ug - 1.0ug/ml, This product does not require protein digestion pre-treatment of paraffin embedded sections e.g. trypsin or pronase prior to staining. Recommended Positive Control: Human heart tissue. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS containing 0.02% Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf Life: one year from despatch.
Expiry Date 12 months
General Kostura, Tocci, Limjuco et al.: "Identification of a monocyte specific pre-interleukin 1 beta convertase activity." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 86, Issue 14, pp. 5227-31, 1989 (PubMed).

Miura, Zhu, Rotello et al.: "Induction of apoptosis in fibroblasts by IL-1 beta-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3." in: Cell, Vol. 75, Issue 4, pp. 653-60, 1993 (PubMed).

Ghayur, Banerjee, Hugunin et al.: "Caspase-1 processes IFN-gamma-inducing factor and regulates LPS-induced IFN-gamma production." in: Nature, Vol. 386, Issue 6625, pp. 619-23, 1997 (PubMed).

Fantuzzi, Puren, Harding et al.: "Interleukin-18 regulation of interferon gamma production and cell proliferation as shown in interleukin-1beta-converting enzyme (caspase-1)-deficient mice." in: Blood, Vol. 91, Issue 6, pp. 2118-25, 1998 (PubMed).

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