LPAM-1 antibody

Details for Product No. ABIN135383
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Antigen
Reactivity
Mouse (Murine)
(18)
Host
Rat
(18)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(6), (3), (3)
Application
Flow Cytometry (FACS), Immunohistochemistry (IHC)
(16), (8), (2), (2)
Pubmed 2 references available
Quantity 0.5 mg
Options
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Catalog No. ABIN135383
368.50 $
Plus shipping costs $45.00 and $26.40 dry ice

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Immunogen AKR/Cum mouse spontaneous T lymphoma cell line TK1 1
Clone DATK32
Isotype IgG2a
Characteristics The antibody detects: Mouse LPAM-1 (Integrin 47)
The monoclonal antibody DATK32 recognizes a conformational epitope on the heterodimer.
Endotoxin Level Low Endotoxin
Background The lymphocyte Peyer's patch adhesion molecule (LPAM-1), also known as integrin 47, is a member of the integrin family of cell surface receptors. It is expressed primarily on mucosal lymphocytes, but is also present on NK cells and eosinophils. The 47 heterodimer mediates the binding of lymphocytes to its ligand, mucosal vascular addressin (MAdCAM-1) on the high endothelial venules, thereby directing the homing of lymphocytes into Peyer's patches and intestinal lamina propria.
Application Notes Working Dilution:
FACS: 1 µg/10^6 cells
Representative data are included in this product insert.

Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.
Comment

Blockade of binding to cell adhesion molecules, Induction of homotypic cellular aggregation

Sample Volume 1 mL
Restrictions For Research Use only
Buffer Product is supplied as 0.5 mg purified immunoglobulin in 1.0 mL of PBS.
Preservative Azide free
Handling Advice Each reagent is stable for the period shown on the bottle label if stored as directed.
Storage -20 °C
Storage Comment Aliquot and freeze the low endotoxin, azide-free product at -20 °C immediately upon receipt.
General Andrew, Berlin, Honda et al.: "Distinct but overlapping epitopes are involved in alpha 4 beta 7-mediated adhesion to vascular cell adhesion molecule-1, mucosal addressin-1, fibronectin, and lymphocyte aggregation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 153, Issue 9, pp. 3847-61, 1994 (PubMed).

Berlin, Berg, Briskin et al.: "Alpha 4 beta 7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1." in: Cell, Vol. 74, Issue 1, pp. 185-95, 1993 (PubMed).

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