ITGA4 antibody (AA 376-558)

Catalog No. ABIN7156438

Product Details anti-ITGA4 Antibody

Target: ITGA4 (Integrin alpha 4 (ITGA4))

Binding Specificity: AA 376-558

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ITGA4 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Integrin alpha-4 protein (376-558AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for ITGA4

Target: ITGA4 (Integrin alpha 4 (ITGA4))

Alternative Name: ITGA4 (ITGA4 Products)

Synonyms: CD49D antibody, IA4 antibody, LOC100219853 antibody, integrin subunit alpha 4 antibody, integrin alpha 4 antibody, integrin subunit alpha 4 S homeolog antibody, ITGA4 antibody, Itga4 antibody, itga4.S antibody

Background:

Background: Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells. ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415). ITGA4:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877).

Aliases: 269C wild type antibody, Antigen CD49D, alpha 4 subunit of VLA 4 receptor antibody, CD49 antigen like family member D antibody, CD49 antigen-like family member D antibody, CD49d antibody, IA4 antibody, Integrin alpha 4 antibody, Integrin alpha 4 subunit antibody, Integrin alpha IV antibody, Integrin alpha-4 antibody, Integrin alpha-IV antibody, Integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA 4 receptor) antibody, ITA4_HUMAN antibody, ITGA4 antibody, MGC90518 antibody, OTTHUMP00000205320 antibody, Very late activation protein 4 receptor, alpha 4 subunit antibody, VLA 4 subunit alpha antibody, VLA-4 subunit alpha antibody, VLA4 antibody

UniProt: P13612

Pathways: Integrin Complex