ITGA4 antibody (C-Term)

Catalog No. ABIN3021106

The Rabbit Polyclonal anti-ITGA4 antibody is suitable to detect ITGA4 in samples from Human. It has been validated for WB and IHC.

Quick Overview for ITGA4 antibody (C-Term) (ABIN3021106)

Target: ITGA4 (Integrin alpha 4 (ITGA4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ITGA4 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-ITGA4 Antibody

Binding Specificity: C-Term

Sequence: FLCNFGKMES GKEASVHIQL EGRPSILEMD ETSALKFEIR ATGFPEPNPR VIELNKDENV AHVLLEGLHH QRPKRYFTIV IISSSLLLGL IVLLLISYVM WKAGFFKRQY KSILQEENRR DSWSYINSKS NDD

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 900 to the C-terminus of human Integrin alpha 4 (ITGA4/CD49d) (NP_000876.3).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for ITGA4

Target: ITGA4 (Integrin alpha 4 (ITGA4))

Alternative Name: ITGA4

Background: The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 4 subunit. This subunit associates with a beta 1 or beta 7 subunit to form an integrin that may play a role in cell motility and migration. This integrin is a therapeutic target for the treatment of multiple sclerosis, Crohn's disease and inflammatory bowel disease. Alternative splicing results in multiple transcript variants.,ITGA4,CD49D,IA4,Signal Transduction,G protein signaling,G2/M DNA Damage Checkpoint,PI3K-Akt Signaling Pathway,MAPK-Erk Signaling Pathway,Cell Biology & Developmental Biology,Cell Adhesion,Cytoskeleton,Immunology & Inflammation,CD markers,Stem Cells,Neural Stem Cells,ITGA4

Molecular Weight: 21 kDa/114 kDa

Gene ID: 3676

UniProt: P13612

Pathways: Integrin Complex