Integrin beta 3 antibody

Catalog No. ABIN1449278

Product Details anti-Integrin beta 3 Antibody

Target: Integrin beta 3 (ITGB3)

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This Integrin beta 3 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunoprecipitation (IP)

Cross-Reactivity (Details): Species reactivity (tested):Mouse. Not Human (PBCM cells on Flow cytometry).

Purification: Protein G agarose

Immunogen: Mouse platelet

Clone: 1-55-4

Isotype: IgG2a

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 50 % glycerol, pH 7.2. No preservative is contained.

Preservative: Without preservative

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Upon receipt, store (in aliqouts) at -20 °C.

Target Details for Integrin beta 3

Target: Integrin beta 3 (ITGB3)

Alternative Name: CD61 / ITGB3 (ITGB3 Products)

Background: Platelet activation results in a conformational change of the membrane spanning platelet integrin GPIIb/IIIa (aIIbß3, CD41/CD61) enabling the binding of the plasma protein fibrinogen. This binding is primarily reversible, but it enhances platelet activation by outside-in signal causing receptor clustering, platelet secretion, and finally irreversible fibrinogen binding and platelet aggregation.Synonyms: GP3A, GPIIIa, Integrin beta-3, Platelet membrane glycoprotein IIIa

Gene ID: 10090

UniProt: O54890

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Signaling Events mediated by VEGFR1 and VEGFR2, Smooth Muscle Cell Migration, Integrin Complex