IL-6 Receptor antibody

Catalog No. ABIN1722533

Product Details anti-IL-6 Receptor Antibody

Target: IL-6 Receptor (IL6R) (Interleukin 6 Receptor (IL6R))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This IL-6 Receptor antibody is un-conjugated

Application: Immunoprecipitation (IP), ELISA, Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Functional Studies (Func)

Specificity: Reacts with human Interleukin-6 Rα subunit, IL-6 Ra, IL-6 R, a 80 kDa protein

Cross-Reactivity (Details): Recognizes soluble and membrane bound IL-6 R

Purification: Purified

Immunogen: CD126/gp80 transfected CHO cell line

Clone: B-R6

Isotype: IgG1

Application Details

Application Notes:

Working dilution: Blocks IL-6 induced proliferation of XG-1 cells, Inhibits IL-6 binding to its receptor

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: PBS. Sterile-filtered through 0.22 μm and treated to remove endotoxins. Carrier and preservative free, Azide free

Preservative: Azide free

Storage: 4 °C

Storage Comment: Stable at +2-8°C for 12 months For longer storage, freeze aliquots

Expiry Date: 12 months

Target Details for IL-6 Receptor

Target: IL-6 Receptor (IL6R) (Interleukin 6 Receptor (IL6R))

Alternative Name: CD126 (IL6R Products)

Background: Subunit alpha of the interleukin-6 receptor. Needs to be associated to IL6ST to transduce signal.

Gene ID: 3570

UniProt: P08887

Pathways: JAK-STAT Signaling, Autophagy, Growth Factor Binding, Cancer Immune Checkpoints