ABCG5 antibody (AA 306-367)

Catalog No. ABIN1724806

Product Details anti-ABCG5 Antibody

Target: ABCG5 (ATP-Binding Cassette, Sub-Family G (WHITE), Member 5 (ABCG5))

Binding Specificity: AA 306-367

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ABCG5 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Purpose: ABCG5 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human ABCG5 (AA: 306-367) expressed in E. Coli.

Clone: 1B5D8

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-ABCG5 antibody (ABIN1724806)

Li, Yin, Wei, Yan, Aung, Wu, Wu, Lin, Liu, Pan: "ATP-binding cassette transporter G5 and G8 polymorphisms and several environmental factors with serum lipid levels." in: PLoS ONE, Vol. 7, Issue 5, pp. e37972, (2012) (PubMed).

Jakulj, Vissers, Tanck, Hutten, Stellaard, Kastelein, Dallinga-Thie: "ABCG5/G8 polymorphisms and markers of cholesterol metabolism: systematic review and meta-analysis." in: Journal of lipid research, Vol. 51, Issue 10, pp. 3016-23, (2010) (PubMed).

Target Details for ABCG5

Target: ABCG5 (ATP-Binding Cassette, Sub-Family G (WHITE), Member 5 (ABCG5))

Alternative Name: ABCG5 (ABCG5 Products)

Background:

Description: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. The protein encoded by this gene functions as a half-transporter to limit intestinal absorption and promote biliary excretion of sterols. It is expressed in a tissue-specific manner in the liver, colon, and intestine. This gene is tandemly arrayed on chromosome 2, in a head-to-head orientation with family member ABCG8. Mutations in this gene may contribute to sterol accumulation and atheroschlerosis, and have been observed in patients with sitosterolemia.

Aliases: STSL

Molecular Weight: 72.5kDa

Gene ID: 64240

HGNC: 64240

Pathways: Lipid Metabolism