ABCG5 antibody (ATP-Binding Cassette, Sub-Family G (WHITE), Member 5) (AA 306-367)

Details for Product anti-ABCG5 Antibody No. ABIN1724857
Antigen
Epitope
AA 306-367
4
4
4
2
1
1
1
1
1
Reactivity
Human
50
20
19
2
2
2
1
1
Host
Mouse
47
4
Clonality (Clone)
Monoclonal ()
Conjugate
This ABCG5 antibody is un-conjugated
3
2
2
2
2
2
2
2
2
1
1
1
1
1
Application
Flow Cytometry (FACS), Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
28
16
13
7
6
4
1
1
Options
Immunogen Purified recombinant fragment of human ABCG5 (AA 306-367) expressed in E. Coli.
Clone 1B5E10
Isotype IgG1
Purification Purified
Antigen
Alternative Name ABCG5 (ABCG5 Antibody Abstract)
Background The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. The protein encoded by this gene functions as a half-transporter to limit intestinal absorption and promote biliary excretion of sterols. It is expressed in a tissue-specific manner in the liver, colon, and intestine. This gene is tandemly arrayed on chromosome 2, in a head-to-head orientation with family member ABCG8. Mutations in this gene may contribute to sterol accumulation and atheroschlerosis, and have been observed in patients with sitosterolemia. , ,
Molecular Weight 72.5 kDa
Gene ID 64240
HGNC 64240
Pathways Lipid Metabolism
Application Notes ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, FCM: 1:200 - 1:400
Restrictions For Research Use only
Format Liquid
Buffer PBS with 0.05 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C,-20 °C
Storage Comment 4°C, -20°C for long term storage
Supplier Images
Image no. 1 for anti-ATP-Binding Cassette, Sub-Family G (WHITE), Member 5 (ABCG5) (AA 306-367) antibody (ABIN1724857) Immunohistochemical analysis of paraffin-embedded cervical cancer tissues using ABCG5...
Image no. 2 for anti-ATP-Binding Cassette, Sub-Family G (WHITE), Member 5 (ABCG5) (AA 306-367) antibody (ABIN1724857) Immunohistochemical analysis of paraffin-embedded rectum cancer tissues using ABCG5 m...
Product cited in: Li, Yin, Wei, Yan, Aung, Wu, Wu, Lin, Liu, Pan: "ATP-binding cassette transporter G5 and G8 polymorphisms and several environmental factors with serum lipid levels." in: PLoS ONE, Vol. 7, Issue 5, pp. e37972, 2012 (PubMed).

Johnson, Lee, Pickert, Urbatsch: "Bile acids stimulate ATP hydrolysis in the purified cholesterol transporter ABCG5/G8." in: Biochemistry, Vol. 49, Issue 16, pp. 3403-11, 2010 (PubMed).