TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 2 (TAB2) (N-Term) antibody

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Antigen
Synonyms CHTD2, MAP3K7IP2, 1110030N06Rik, A530078N03Rik, Map3k7ip2, mKIAA0733, map3k7ip2, zgc:77446
Alternatives
Epitope
N-Term
(9), (5), (5), (5), (3), (2), (2), (1), (1), (1), (1), (1)
Reactivity
Chicken, Cow (Bovine), Dog (Canine), Human, Mouse (Murine), Rat (Rattus)
(48), (7), (6), (3), (2)
Host
Rabbit
(24), (14), (10)
Clonality
Polyclonal
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(26), (17), (13), (12), (9), (6), (4), (2), (1)
Pubmed 2 references available
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Quantity 50 μg
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Immunogen Synthetic peptide directed towards the N terminal of human MAP3K7IP2
Blocking Peptide Blocking peptide for this product available: TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 2 (TAB2) peptide (ABIN979779)
Sequence QKFPEVPEVV VSRCMLQNNN NLDACCAVLS QESTRYLYGE GDLNFSDDSG
Predicted Reactivity Mouse :100 %,   Bovine :100 %,   Dog :100 %,   Rat :100 %,   Human :100 %,   Chicken :80 %,  
Characteristics This is a rabbit polyclonal antibody against MAP3K7IP2. It was validated on Western Blot and immunohistochemistry.
Purification Affinity Purified
Alternative Name MAP3K7IP2 (TAB2 Antibody Abstract)
Background MAP3K7IP2 is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of NF.:B and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serving as an adaptor linking MAP3K7 and TRAF6. This protein, TAB1, and MAP3K7 also participate in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF.:B (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts.
Molecular Weight 76 kDa
Gene ID 23118
NCBI Accession NP_055908, NM_015093
UniProt Q9NYJ8
Pathways TLR Signaling, Fc-epsilon Receptor Signaling Pathway
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 693 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
Western Blotting (WB) image for anti-TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 2 (TAB2) (N-Term) antibody (ABIN182562) WB Suggested Anti-MAP3K7IP2 Antibody Titration: 0.2-1 ug/ml
Positive Con...
Immunohistochemistry (IHC) image for anti-TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 2 (TAB2) (N-Term) antibody (ABIN182562) anti-TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 2 (TAB2) (N-Term) antibody (Image 2)
Immunohistochemistry (IHC) image for anti-TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 2 (TAB2) (N-Term) antibody (ABIN182562) anti-TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 2 (TAB2) (N-Term) antibody (Image 3)
Western Blotting (WB) image for anti-TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 2 (TAB2) (N-Term) antibody (ABIN182562) WB Suggested Anti-MAP3K7IP2
Antibody Titration: 0.2-1 µg/mL
Positive Co...
Product cited in: Thienpont, Zhang, Postma et al.: "Haploinsufficiency of TAB2 causes congenital heart defects in humans." in: American journal of human genetics, Vol. 86, Issue 6, pp. 839-49, 2010 (PubMed).

Background publications Kanayama, Seth, Sun et al.: "TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains." in: Molecular cell, Vol. 15, Issue 4, pp. 535-48, 2004 (PubMed).

Catalog No. ABIN182562
$289.00
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