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TAB2 antibody

TAB2 Reactivity: Human WB, ELISA, FACS Host: Mouse Monoclonal 3B5 unconjugated
Catalog No. ABIN969430
  • Target See all TAB2 Antibodies
    TAB2 (TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 2 (TAB2))
    Reactivity
    • 17
    • 8
    • 7
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 17
    • 2
    Mouse
    Clonality
    • 19
    Monoclonal
    Conjugate
    • 19
    This TAB2 antibody is un-conjugated
    Application
    • 14
    • 6
    • 6
    • 5
    • 3
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Flow Cytometry (FACS)
    Purification
    purified
    Immunogen
    Purified recombinant fragment of human TAB2 expressed in E. coli.
    Clone
    3B5
    Isotype
    IgG1
    Top Product
    Discover our top product TAB2 Primary Antibody
  • Application Notes
    ELISA: 1:10000, WB: 1:500 - 1:2000, FCM: 1:200 - 1:400
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Ascitic fluid containing 0.03 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C/-20 °C
    Storage Comment
    4°C, -20°C for long term storage
  • Thienpont, Zhang, Postma, Breckpot, Tranchevent, Van Loo, Møllgård, Tommerup, Bache, Tümer, van Engelen, Menten, Mortier, Waggoner, Gewillig, Moreau, Devriendt, Larsen: "Haploinsufficiency of TAB2 causes congenital heart defects in humans." in: American journal of human genetics, Vol. 86, Issue 6, pp. 839-49, (2010) (PubMed).

    Häcker, Karin: "Regulation and function of IKK and IKK-related kinases." in: Science's STKE : signal transduction knowledge environment, Vol. 2006, Issue 357, pp. re13, (2006) (PubMed).

    Simmonds, Heward, Carr-Smith, Foxall, Franklyn, Gough: "Contribution of single nucleotide polymorphisms within FCRL3 and MAP3K7IP2 to the pathogenesis of Graves' disease." in: The Journal of clinical endocrinology and metabolism, Vol. 91, Issue 3, pp. 1056-61, (2006) (PubMed).

  • Target
    TAB2 (TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 2 (TAB2))
    Alternative Name
    TAB2 (TAB2 Products)
    Synonyms
    CHTD2 antibody, MAP3K7IP2 antibody, 1110030N06Rik antibody, A530078N03Rik antibody, Map3k7ip2 antibody, mKIAA0733 antibody, map3k7ip2 antibody, zgc:77446 antibody, TGF-beta activated kinase 1/MAP3K7 binding protein 2 antibody, TAB2 antibody, Tab2 antibody, tab2 antibody
    Background

    Description: The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serves as an adaptor linking MAP3K7 and TRAF6. This protein, TAB1, and MAP3K7 also participate in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts.

    Aliases: CHTD2, FLJ21885, KIAA0733, MAP3K7IP2, TAB2

    Molecular Weight
    80 kDa
    Gene ID
    23118
    HGNC
    23118
    Pathways
    TCR Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades, Ubiquitin Proteasome Pathway
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