Prenylcysteine Oxidase 1 (PCYOX1) (C-Term) antibody

Details for Product No. ABIN182725
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Antigen
Synonyms pcl1, zgc:110246, PCYOX1, DKFZp459K115, PCL1, Clp55, 1200015P13Rik, AI115532, AI448340, Pcly
Epitope
C-Term
(2), (1), (1), (1)
Reactivity
Dog (Canine), Cow (Bovine), Human
(8), (3), (2), (1), (1)
Host
Rabbit
(6), (3)
Clonality
Polyclonal
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(6), (6), (3), (2), (2), (1), (1)
Pubmed 2 references available
Quantity 100 μg
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Catalog No. ABIN182725
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Immunogen Synthetic peptide directed towards the C terminal of human PCYOX1
Sequence IFSQETLTKA QILKLFLSYD YAVKKPWLAY PHYKPPEKCP SIILHDRLYY
Predicted Reactivity Human : 100 %, Rabbit : 100 %, Dog : 80 %, Horse : 80 %
Characteristics This is a rabbit polyclonal antibody against PCYOX1. It was validated on Western Blot and immunohistochemistry.
Purification Protein A purified
Alternative Name PCYOX1
Background Prenylated proteins contain one of two isoprenoid lipids, either the 15-carbon farnesyl or the 20-carbon geranylgeranyl, covalently attached to cysteine residues at or near their C terminus. PCYOX1 is capable of cleaving the thioether bond of prenylcysteines. The enzyme was isolated from bovine brain membranes and exhibits an apparent molecular mass of 63 kDa. This is a specific enzyme involved in prenylcysteine metabolism in mammalian cells, most likely comprising the final step in the degradation of prenylated proteins.
Molecular Weight 57 kDa
Gene ID 51449
NCBI Accession NM_016297, NP_057381
UniProt Q9UHG3
Research Area Signaling, Metabolism, Organelles
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 505 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 100 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-Prenylcysteine Oxidase 1 (PCYOX1) (C-Term) antibody WB Suggested Anti-PCYOX1 Antibody Titration: 0.5ug/ml
Positive Control: Jurkat cell lysate
anti-Prenylcysteine Oxidase 1 (PCYOX1) (C-Term) antibody (2) anti-Prenylcysteine Oxidase 1 (PCYOX1) (C-Term) antibody (Image 2)
Background publications Clark, Gurney, Abaya et al.: "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. ..." in: Genome research, Vol. 13, Issue 10, pp. 2265-70, 2003 (PubMed).

General Clark, Edwards, Peterson et al.: "Fugu ESTs: new resources for transcription analysis and genome annotation." in: Genome research, Vol. 13, Issue 12, pp. 2747-53, 2003 (PubMed).

Validation Images
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