Small Conductance Calcium-Activated Potassium Channel Protein 3 (KCNN3) (C-Term) antibody

Details for Product No. ABIN183133
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Antigen
Synonyms KCa2.3, SK3, SKCA3, hSK3
Epitope
C-Term
(7), (1), (1)
Reactivity
Mouse (Murine), Rat (Rattus), Dog (Canine), Cow (Bovine), Pig (Porcine), Human
(23), (20), (19), (15), (13), (13), (12)
Host
Rabbit
(21), (3)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(14), (10), (4), (2), (2), (1), (1), (1)
Pubmed 1 reference available
Quantity 50 μg
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Catalog No. ABIN183133
289.00 $
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Immunogen Synthetic peptide directed towards the C terminal of human KCNN3
Sequence ITELNDRSED LEKQIGSLES KLEHLTASFN SLPLLIADTL RQQQQQLLSA
Predicted Reactivity Bovine : 100 %, Dog : 100 %, Guinea pig : 100 %, Human : 100 %, Mouse : 100 %, Pig : 100 %, Rabbit : 100 %, Rat : 100 %
Characteristics This is a rabbit polyclonal antibody against KCNN3. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name KCNN3
Background Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. KCNN3, a member of the KCNN family of potassium channel genes, encodes a protein that is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits.
Molecular Weight 81 kDa
Gene ID 3782
NCBI Accession NM_002249, NP_002240
UniProt Q9UGI6
Research Area Neurology
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 736 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-Small Conductance Calcium-Activated Potassium Channel Protein 3 (KCNN3) (C-Term) antibody WB Suggested Anti-KCNN3 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:62500
Positive Control: Daudi cell lysate
anti-Small Conductance Calcium-Activated Potassium Channel Protein 3 (KCNN3) (C-Term) antibody (2) anti-Small Conductance Calcium-Activated Potassium Channel Protein 3 (KCNN3) (C-Term) antibody (Image 2)
anti-Small Conductance Calcium-Activated Potassium Channel Protein 3 (KCNN3) (C-Term) antibody (3) KCNN3 Antibody - C-terminal region (ARP35097_P050) validated by WB using Mouse kidney , Whole brain lysate at 2 µg/mL.
anti-Small Conductance Calcium-Activated Potassium Channel Protein 3 (KCNN3) (C-Term) antibody (4) WB Suggested Anti-KCNN3
Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.2500
Positive Control: Daudi cell lysate
KCNN3 is supported by BioGPS gene expression data to be expressed in Daudi
Background publications Kolski-Andreaco, Tomita, Shakkottai et al.: "SK3-1C, a dominant-negative suppressor of SKCa and IKCa channels." in: The Journal of biological chemistry, Vol. 279, Issue 8, pp. 6893-904, 2004 (PubMed).

Validation Images
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