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Details for Product No. ABIN183133

Small Conductance Calcium-Activated Potassium Channel Protein 3 (KCNN3) (C-Term) antibody

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Antigen
Synonyms KCa2.3, SK3, SKCA3, hSK3
Epitope
»Alternatives C-Term
Reactivity
»Alternatives Mouse (Murine), Rat (Rattus), Dog (Canine), Cow (Bovine), Pig (Porcine), Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN183133
Quantity 50 µg
Price
289.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen The immunogen for anti-KCNN3 antibody: synthetic peptide directed towards the C terminal of human KCNN3
Sequence ITELNDRSEDLEKQIGSLESKLEHLTASFNSLPLLIADTL RQQQQQLLSA
Predicted Reactivity Bovine : 100%, Dog : 100%, Guinea pig : 100%, Human : 100%, Mouse : 100%, Pig : 100%, Rabbit : 100%, Rat : 100%
Characteristics This is a rabbit polyclonal antibody against KCNN3. It was validated on Western Blot using a cell lysate as a positive control. We strive to provide antibodies covering each member of a whole protein family of your interest.
Purification Affinity Purified
Alternative Name KCNN3
Background Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. KCNN3, a member of the KCNN family of potassium channel genes, encodes a protein that is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits.
Molecular Weight 81kDa
Gene ID 3782
NCBI Accession NP_002240, NM_002249
UniProt Q9UGI6
Research Area Neurology
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water
Concentration 1mg/mL
Buffer Final anti-KCNN3 antibody concentration is 1 mg/mL in PBS buffer.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Background publications Kolski-Andreaco, Tomita, Shakkottai et al.: "SK3-1C, a dominant-negative suppressor of SKCa and IKCa channels." in: The Journal of biological chemistry, Vol. 279, Issue 8, pp. 6893-904, 2004 (PubMed).

Alternatives for antigen "Small Conductance Calcium-Activated Potassium Channel Protein 3 (KCNN3)", type "Antibodies"
Hosts (18), (3), (1)
Reactivities (19), (15), (14), (13), (13), (13), (12)
Applications (12), (10), (6), (4), (1), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (4), (1)
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