KCNN3 antibody (C-Term)

Catalog No. ABIN633755

Product Details anti-KCNN3 Antibody

Target: KCNN3 (Small Conductance Calcium-Activated Potassium Channel Protein 3 (KCNN3))

Binding Specificity: C-Term

Reactivity: Human, Rat, Mouse, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KCNN3 antibody is un-conjugated

Application: Western Blotting (WB)

Specificity: KCNN3 antibody was raised against the C terminal of KCNN3

Purification: Affinity purified

Immunogen: KCNN3 antibody was raised using the C terminal of KCNN3 corresponding to a region with amino acids ITELNDRSEDLEKQIGSLESKLEHLTASFNSLPLLIADTLRQQQQQLLSA

Application Details

Application Notes: WB: 2 µg/mL
Optimal conditions should be determined by the investigator.

Comment:

KCNN3 Blocking Peptide, catalog no. 33R-4172, is also available for use as a blocking control in assays to test for specificity of this KCNN3 antibody

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Lyophilized powder. Add distilled water for a 1 mg/mL concentration of KCNN3 antibody in PBS

Concentration: Lot specific

Buffer: PBS

Handling Advice: Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2-8 °C for short periods. For longer periods of storage, store at -20 °C.

Target Details for KCNN3

Target: KCNN3 (Small Conductance Calcium-Activated Potassium Channel Protein 3 (KCNN3))

Alternative Name: KCNN3 (KCNN3 Products)

Synonyms: KCa2.3 antibody, SK3 antibody, SKCA3 antibody, hSK3 antibody, potassium calcium-activated channel subfamily N member 3 antibody, potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3 antibody, Kcnn3 antibody, KCNN3 antibody

Background: Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. KCNN3, a member of the KCNN family of potassium channel genes, encodes a protein that is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits.

Molecular Weight: 81 kDa (MW of target protein)