anti-PRMT2 antibody (Protein Arginine Methyltransferase 2) (N-Term)

Details for Product anti-PRMT2 Antibody No. ABIN183891
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Antigen
Synonyms PRMT2, DKFZp459N1919, HRMT1L1, Hrmt1l1, AI504737
Epitope
N-Term
(25), (18), (3), (2), (2), (2), (1), (1), (1), (1), (1)
Reactivity
Cow (Bovine), Dog (Canine), Human, Mouse (Murine), Pig (Porcine), Rat (Rattus)
(103), (8), (8), (2), (1), (1)
Host
Rabbit
(63), (31), (9)
Clonality
Polyclonal
Conjugate
This PRMT2 antibody is un-conjugated
(5), (5), (5), (5), (5), (5)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(88), (41), (24), (23), (7), (6), (4), (3), (2), (2), (2)
Pubmed 4 references available
Quantity 100 μg
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Immunogen Synthetic peptide directed towards the N terminal of human PRMT2
Sequence ESQGEEPAEC SEAGLLQEGV QPEEFVAIAD YAATDETQLS FLRGEKILIL
Predicted Reactivity Bovine : 100 %, Horse : 100 %, Human : 100 %, Mouse : 100 %, Rat : 100 %, Dog : 90 %, Guinea pig : 90 %
Characteristics This is a rabbit polyclonal antibody against PRMT2. It was validated on Western Blot and immunohistochemistry.
Purification Protein A purified
Alternative Name PRMT2 (PRMT2 Antibody Abstract)
Background The protein arginine methyltransferases (PRMTs) include a family of proteins with related putative methyltransferase domains that modify chromatin and regulate cellular transcription. PRMT2 inhibits NF-kappaB-dependent transcription and promotes apoptosis and it exerts this effect by blocking nuclear export of IkappaB-alpha through a leptomycin-sensitive pathway, increasing nuclear IkappaB-alpha and decreasing NF-kappaB DNA binding. PRMT2 also rendered cells susceptible to apoptosis by cytokines or cytotoxic drugs, likely due to its effects on NF-kappaB.
Molecular Weight 48 kDa
Gene ID 3275
NCBI Accession NP_001526, NM_001535
UniProt P55345
Research Area Chromatin and Nuclear Signaling
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 433 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 100 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-Protein Arginine Methyltransferase 2 (PRMT2) (N-Term) antibody WB Suggested Anti-PRMT2 Antibody Titration: 0.625ug/ml
ELISA Titer: ...
anti-Protein Arginine Methyltransferase 2 (PRMT2) (N-Term) antibody (2) anti-Protein Arginine Methyltransferase 2 (PRMT2) (N-Term) antibody (Image 2)
anti-Protein Arginine Methyltransferase 2 (PRMT2) (N-Term) antibody (3) anti-Protein Arginine Methyltransferase 2 (PRMT2) (N-Term) antibody (Image 3)
anti-Protein Arginine Methyltransferase 2 (PRMT2) (N-Term) antibody (4) PRMT2 Antibody - N-terminal region (ARP40196_T100) validated by WB using human LCL an...
Product cited in: Burton, Muller, Tu et al.: "Single-cell profiling of epigenetic modifiers identifies PRDM14 as an inducer of cell fate in the mammalian embryo." in: Cell reports, Vol. 5, Issue 3, pp. 687-701, 2013 (PubMed).

Zhong, Cao, Zu et al.: "Identification and characterization of novel spliced variants of PRMT2 in breast carcinoma." in: The FEBS journal, Vol. 279, Issue 2, pp. 316-35, 2012 (PubMed).

Zhong, Cao, Hong et al.: "Identification and expression analysis of a novel transcript of the human PRMT2 gene resulted from alternative polyadenylation in breast cancer." in: Gene, Vol. 487, Issue 1, pp. 1-9, 2011 (PubMed).

Background publications Qi, Chang, Zhu et al.: "Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha." in: The Journal of biological chemistry, Vol. 277, Issue 32, pp. 28624-30, 2002 (PubMed).

Validation Images
Catalog No. ABIN183891
229.00 $
Plus shipping costs $45.00
Quantity
Price
100 μg
229.00 $

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