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PRMT2 antibody (Protein Arginine Methyltransferase 2) (N-Term)

Details for Product anti-PRMT2 Antibody No. ABIN183891, Supplier: Login to see New
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(28), (20), (3), (3), (3), (3), (2), (2), (2), (2)
Cow (Bovine), Dog (Canine), Human, Mouse (Murine), Pig (Porcine), Rat (Rattus)
(113), (10), (10), (3), (2), (2)
(73), (31), (9)
This PRMT2 antibody is un-conjugated
(5), (5), (5), (5), (5), (5)
Immunohistochemistry (IHC), Western Blotting (WB)
(95), (49), (29), (25), (7), (5), (3), (2), (2), (1)
Pubmed 4 references available
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Quantity 100 μg
Shipping to United States ( )
Immunogen Synthetic peptide directed towards the N terminal of human PRMT2
Predicted Reactivity Bovine : 100 %, Horse : 100 %, Human : 100 %, Mouse : 100 %, Rat : 100 %, Dog : 90 %, Guinea pig : 90 %
Characteristics This is a rabbit polyclonal antibody against PRMT2. It was validated on Western Blot and immunohistochemistry.
Purification Protein A purified
Alternative Name PRMT2 (PRMT2 Antibody Abstract)
Background The protein arginine methyltransferases (PRMTs) include a family of proteins with related putative methyltransferase domains that modify chromatin and regulate cellular transcription. PRMT2 inhibits NF-kappaB-dependent transcription and promotes apoptosis and it exerts this effect by blocking nuclear export of IkappaB-alpha through a leptomycin-sensitive pathway, increasing nuclear IkappaB-alpha and decreasing NF-kappaB DNA binding. PRMT2 also rendered cells susceptible to apoptosis by cytokines or cytotoxic drugs, likely due to its effects on NF-kappaB.
Molecular Weight 48 kDa
Gene ID 3275
NCBI Accession NP_001526, NM_001535
UniProt P55345
Research Area Chromatin and Nuclear Signaling
Application Notes Optimal working dilutions should be determined experimentally by the investigator.

Antigen size: 433 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 100 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
Western Blotting (WB) image for anti-PRMT2 antibody (Protein Arginine Methyltransferase 2) (N-Term) (ABIN183891) WB Suggested Anti-PRMT2 Antibody Titration: 0.625ug/ml
ELISA Titer: ...
Image no. 2 for anti-PRMT2 antibody (Protein Arginine Methyltransferase 2) (N-Term) (ABIN183891) anti-Protein Arginine Methyltransferase 2 (PRMT2) (N-Term) antibody (Image 2)
Immunohistochemistry (IHC) image for anti-PRMT2 antibody (Protein Arginine Methyltransferase 2) (N-Term) (ABIN183891) anti-Protein Arginine Methyltransferase 2 (PRMT2) (N-Term) antibody (Image 3)
Western Blotting (WB) image for anti-PRMT2 antibody (Protein Arginine Methyltransferase 2) (N-Term) (ABIN183891) PRMT2 Antibody - N-terminal region (ARP40196_T100) validated by WB using human LCL an...
Product cited in: Burton, Muller, Tu et al.: "Single-cell profiling of epigenetic modifiers identifies PRDM14 as an inducer of cell fate in the mammalian embryo." in: Cell reports, Vol. 5, Issue 3, pp. 687-701, 2013 (PubMed).

Zhong, Cao, Zu et al.: "Identification and characterization of novel spliced variants of PRMT2 in breast carcinoma." in: The FEBS journal, Vol. 279, Issue 2, pp. 316-35, 2012 (PubMed).

Zhong, Cao, Hong et al.: "Identification and expression analysis of a novel transcript of the human PRMT2 gene resulted from alternative polyadenylation in breast cancer." in: Gene, Vol. 487, Issue 1, pp. 1-9, 2011 (PubMed).

Background publications Qi, Chang, Zhu et al.: "Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha." in: The Journal of biological chemistry, Vol. 277, Issue 32, pp. 28624-30, 2002 (PubMed).

Catalog No. ABIN183891

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