Small Nuclear Ribonucleoprotein 70kDa (U1) (SNRNP70) (N-Term) antibody

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Antigen
Synonyms
rnpu1z, rpu1, snrp70, u170k, u1ap, u1rnp, SNRP70, wu:fc20b04, zgc:136450, 2700022N21Rik, 3200002N22Rik, 70kDa, AI325098, R74807, Rnulp70, Snrp70, Srnp70, U1-70, U1-70K, RNPU1Z, RPU1, Snp1, U170K, U1AP ... show more
rnpu1z, rpu1, snrp70, u170k, u1ap, u1rnp, SNRP70, wu:fc20b04, zgc:136450, 2700022N21Rik, 3200002N22Rik, 70kDa, AI325098, R74807, Rnulp70, Snrp70, Srnp70, U1-70, U1-70K, RNPU1Z, RPU1, Snp1, U170K, U1AP, U1RNP show less
Epitope
N-Term
(15), (13), (11), (3), (2), (2), (1)
Reactivity
Cow (Bovine), Dog (Canine), Human, Mouse (Murine), Rat (Rattus), Xenopus laevis, Zebrafish (Danio rerio)
(41), (8), (8), (5), (3), (2), (2), (2), (1)
Host
Rabbit
(36), (3), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (2)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(36), (20), (7), (2)
Pubmed 4 references available
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Quantity 50 μg
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Immunogen Synthetic peptide directed towards the N terminal of human SNRP70
Blocking Peptide Blocking peptide for this product available: Small Nuclear Ribonucleoprotein 70kDa (U1) (SNRNP70) peptide (ABIN984190)
Sequence PHNDPNAQGD AFKTLFVARV NYDTTESKLR REFEVYGPIK RIHMVYSKRS
Predicted Reactivity Mouse :100 %,   Human :100 %,   Western clawed frog :100 %,   Bovine :100 %,   Zebrafish :100 %,   African clawed frog :100 %,   Dog :100 %,   Rat :100 %,   African malaria mosquito :90 %,   Yellowfever mosquito :90 %,   Mosquito :90 %,   Harpegnathos saltator :90 %,   Camponotus floridanus :90 %,   Brown alga :90 %,   Red flour beetle :90 %,   Florida lancelet :90 %,   Black-legged tick :90 %,   Trichoplax reptans :90 %,   Fruit fly :90 %,   Caenorhabditis elegans :80 %,   Caenorhabditis vulgaris :80 %,   Eye worm :80 %,   Body louse :80 %,   Caenorhabditis briggsae :80 %,   Filarial nematode worm :80 %,   Planarian :80 %,   Starlet sea anemone :80 %,   Toxoplasma gondii ME49 :80 %,   Toxoplasma gondii :80 %,   Blood fluke :80 %,   Moss :70 %,   Spikemoss :70 %,   Volvox carteri f. nagariensis :70 %,   Chlorella variabilis :70 %,   Chlamydomonas smithii :70 %,  
Characteristics This is a rabbit polyclonal antibody against SNRP70. It was validated on Western Blot and immunohistochemistry.
Purification Affinity Purified
Alternative Name SNRP70 (SNRNP70 Antibody Abstract)
Background SNRP70 contains 1 RRM (RNA recognition motif) domain and mediates the splicing of pre-mRNA by binding to the loop I region of U1-snRNA.
Molecular Weight 48 kDa
Gene ID 6625
NCBI Accession NM_003089, NP_003080
UniProt P08621
Research Area Chromatin and Nuclear Signaling, Chromatin Binding Proteins, DNA/RNA
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 437 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
Western Blotting (WB) image for anti-Small Nuclear Ribonucleoprotein 70kDa (U1) (SNRNP70) (N-Term) antibody (ABIN183913) WB Suggested Anti-SNRP70 Antibody Titration: 0.2-1 ug/ml
Positive Contro...
Immunohistochemistry (IHC) image for anti-Small Nuclear Ribonucleoprotein 70kDa (U1) (SNRNP70) (N-Term) antibody (ABIN183913) anti-Small Nuclear Ribonucleoprotein 70kDa (U1) (SNRNP70) (N-Term) antibody (Image 2)
Product cited in: Wang, Mueller, Hertel et al.: "G Run-mediated recognition of proteolipid protein and DM20 5' splice sites by U1 small nuclear RNA is regulated by context and proximity to the splice site." in: The Journal of biological chemistry, Vol. 286, Issue 6, pp. 4059-71, 2011 (PubMed).

Wang, Cambi: "Heterogeneous nuclear ribonucleoproteins H and F regulate the proteolipid protein/DM20 ratio by recruiting U1 small nuclear ribonucleoprotein through a complex array of G runs." in: The Journal of biological chemistry, Vol. 284, Issue 17, pp. 11194-204, 2009 (PubMed).

Background publications Zhang, Walker, Tamplin et al.: "Zfp206 regulates ES cell gene expression and differentiation." in: Nucleic acids research, Vol. 34, Issue 17, pp. 4780-90, 2006 (PubMed).

Brandenberger, Wei, Zhang et al.: "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation." in: Nature biotechnology, Vol. 22, Issue 6, pp. 707-16, 2004 (PubMed).

Catalog No. ABIN183913
$289.00
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