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SNRNP70 antibody (N-Term)

SNRNP70 Reactivity: Human, Mouse, Rat, Dog, Cow, Zebrafish (Danio rerio), Guinea Pig, Rabbit, Horse WB, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN183913
  • Target See all SNRNP70 Antibodies
    SNRNP70 (Small Nuclear Ribonucleoprotein 70kDa (U1) (SNRNP70))
    Binding Specificity
    • 7
    • 7
    • 6
    • 6
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 23
    • 8
    • 8
    • 6
    • 5
    • 5
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    Human, Mouse, Rat, Dog, Cow, Zebrafish (Danio rerio), Guinea Pig, Rabbit, Horse
    Host
    • 23
    Rabbit
    Clonality
    • 23
    Polyclonal
    Conjugate
    • 13
    • 2
    • 2
    • 2
    • 2
    • 2
    This SNRNP70 antibody is un-conjugated
    Application
    • 23
    • 14
    • 7
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Sequence
    PHNDPNAQGD AFKTLFVARV NYDTTESKLR REFEVYGPIK RIHMVYSKRS
    Predicted Reactivity
    Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%
    Characteristics
    This is a rabbit polyclonal antibody against SNRP70. It was validated on Western Blot and immunohistochemistry.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the N terminal region of human SNRP70
    Top Product
    Discover our top product SNRNP70 Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 437 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Wang, Mueller, Hertel, Cambi: "G Run-mediated recognition of proteolipid protein and DM20 5' splice sites by U1 small nuclear RNA is regulated by context and proximity to the splice site." in: The Journal of biological chemistry, Vol. 286, Issue 6, pp. 4059-71, (2011) (PubMed).

    Wang, Cambi: "Heterogeneous nuclear ribonucleoproteins H and F regulate the proteolipid protein/DM20 ratio by recruiting U1 small nuclear ribonucleoprotein through a complex array of G runs." in: The Journal of biological chemistry, Vol. 284, Issue 17, pp. 11194-204, (2009) (PubMed).

  • Target
    SNRNP70 (Small Nuclear Ribonucleoprotein 70kDa (U1) (SNRNP70))
    Alternative Name
    SNRP70 (SNRNP70 Products)
    Synonyms
    rnpu1z antibody, rpu1 antibody, snrp70 antibody, u170k antibody, u1ap antibody, u1rnp antibody, SNRP70 antibody, wu:fc20b04 antibody, zgc:136450 antibody, 2700022N21Rik antibody, 3200002N22Rik antibody, 70kDa antibody, AI325098 antibody, R74807 antibody, Rnulp70 antibody, Snrp70 antibody, Srnp70 antibody, U1-70 antibody, U1-70K antibody, RNPU1Z antibody, RPU1 antibody, Snp1 antibody, U170K antibody, U1AP antibody, U1RNP antibody, small nuclear ribonucleoprotein, U1 70kDa subunit antibody, small nuclear ribonucleoprotein U1 subunit 70 antibody, small nuclear ribonucleoprotein 70 (U1) antibody, small nuclear ribonucleoprotein, U1 70kDa subunit L homeolog antibody, snrnp70 antibody, SNRNP70 antibody, Snrnp70 antibody, snrnp70.L antibody
    Background
    SNRP70 contains 1 RRM (RNA recognition motif) domain and mediates the splicing of pre-mRNA by binding to the loop I region of U1-snRNA. Western blots using two different antibodies against two unique regions of this protein target confirm the same apparent molecular weight in our tests.
    Alias Symbols: RPU1, Snp1, U1AP, U170K, U1RNP, RNPU1Z, SNRP70, U1-70K
    Protein Interaction Partner: IL32, UBC, NEDD8, LIN28A, EZH2, SUZ12, EED, RNF2, rev, WBP4, SRPK2, SRPK1, MYC, SRPK3, HDAC2, PAN2, SMURF2, PRPF40A, CDKL3, RNF11, PRKD2, SKIL, RELA, RASGRF1, SMAD9, SMAD5, SMAD4, SMAD3, SMAD2, CHERP, PRMT5, UBL4A, VCAM1, SMAD1, ITGA4, IL7R, IFIT3, IFIT1,
    Protein Size: 437
    Molecular Weight
    52 kDa
    Gene ID
    6625
    NCBI Accession
    NM_003089, NP_003080
    UniProt
    P08621
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