Small Nuclear Ribonucleoprotein 70kDa (U1) (SNRNP70) (C-Term) antibody

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Antigen
Synonyms
rnpu1z, rpu1, snrp70, u170k, u1ap, u1rnp, SNRP70, wu:fc20b04, zgc:136450, 2700022N21Rik, 3200002N22Rik, 70kDa, AI325098, R74807, Rnulp70, Snrp70, Srnp70, U1-70, U1-70K, RNPU1Z, RPU1, Snp1, U170K, U1AP ... show more
rnpu1z, rpu1, snrp70, u170k, u1ap, u1rnp, SNRP70, wu:fc20b04, zgc:136450, 2700022N21Rik, 3200002N22Rik, 70kDa, AI325098, R74807, Rnulp70, Snrp70, Srnp70, U1-70, U1-70K, RNPU1Z, RPU1, Snp1, U170K, U1AP, U1RNP show less
Epitope
C-Term
(15), (13), (11), (4), (2), (1), (1)
Reactivity
Cow (Bovine), Human, Mouse (Murine), Rat (Rattus)
(41), (8), (8), (6), (4), (2), (2), (2), (2)
Host
Rabbit
(36), (3), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (2)
Application
Western Blotting (WB)
(36), (20), (8), (2)
Pubmed 5 references available
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Quantity 50 μg
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Immunogen Synthetic peptide directed towards the C terminal of human SNRP70
Blocking Peptide Blocking peptide for this product available: Small Nuclear Ribonucleoprotein 70kDa (U1) (SNRNP70) peptide (ABIN984192)
Sequence RERERKEELR GGGGDMAEPS EAGDAPPDDG PPGELGPDGP DGPEEKGRDR
Predicted Reactivity Bovine :100 %,   Human :100 %,   Mouse :90 %,   Rat :90 %,  
Characteristics This is a rabbit polyclonal antibody against SNRP70. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name SNRP70 (SNRNP70 Antibody Abstract)
Background SNRP70 contains 1 RRM (RNA recognition motif) domain and mediates the splicing of pre-mRNA by binding to the loop I region of U1-snRNA.
Molecular Weight 51 kDa
Gene ID 6625
NCBI Accession NM_003089, NP_003080
UniProt P08621
Research Area Chromatin and Nuclear Signaling, Chromatin Binding Proteins, DNA/RNA
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 437 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
Western Blotting (WB) image for anti-Small Nuclear Ribonucleoprotein 70kDa (U1) (SNRNP70) (C-Term) antibody (ABIN183955) WB Suggested Anti-SNRP70 Antibody Titration: 0.2-1 ug/ml
ELISA Titer:
Western Blotting (WB) image for anti-Small Nuclear Ribonucleoprotein 70kDa (U1) (SNRNP70) (C-Term) antibody (ABIN183955) WB Suggested Anti-SNRP70
Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.2500 ...
Product cited in: Franklin, Chen, Mitchell-Jordan et al.: "Quantitative analysis of the chromatin proteome in disease reveals remodeling principles and identifies high mobility group protein B2 as a regulator of hypertrophic growth." in: Molecular & cellular proteomics : MCP, Vol. 11, Issue 6, pp. M111.014258, 2012 (PubMed).

Serini, Fasano, Piccioni et al.: "DHA induces apoptosis and differentiation in human melanoma cells in vitro: involvement of HuR-mediated COX-2 mRNA stabilization and β-catenin nuclear translocation." in: Carcinogenesis, Vol. 33, Issue 1, pp. 164-73, 2011 (PubMed).

Franklin, Zhang, Chen et al.: "Specialized compartments of cardiac nuclei exhibit distinct proteomic anatomy." in: Molecular & cellular proteomics : MCP, Vol. 10, Issue 1, pp. M110.000703, 2011 (PubMed).

Background publications Dieker, Cisterna, Monneaux et al.: "Apoptosis-linked changes in the phosphorylation status and subcellular localization of the spliceosomal autoantigen U1-70K." in: Cell death and differentiation, Vol. 15, Issue 4, pp. 793-804, 2008 (PubMed).

Brandenberger, Wei, Zhang et al.: "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation." in: Nature biotechnology, Vol. 22, Issue 6, pp. 707-16, 2004 (PubMed).

Catalog No. ABIN183955
$289.00
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