NLR Family, CARD Domain Containing 4 (NLRC4) (C-Term) antibody

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Antigen
Synonyms CARD12, CLAN, CLAN1, CLANA, CLANB, CLANC, CLAND, CLR2.1, IPAF, 9530011P19Rik, Card12
Epitope
C-Term
(19), (14), (12), (2), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(59), (6), (4)
Host
Rabbit
(56), (4)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(56), (26), (11), (8), (7), (4), (3), (2), (2), (1), (1), (1), (1)
Pubmed 1 reference available
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Quantity 50 μg
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Immunogen Synthetic peptide directed towards the C terminal of human NLRC4
Sequence QLNLAGNRVS SDGWLAFMGV FENLKQLVFF DFSTKEFLPD PALVRKLSQV
Specificity This antibody will recognize NLRC4 isoform 1 (116 kDa) and isoform 2 (46 kDa).
Predicted Reactivity Human : 100 %, Mouse : 80 %, Guinea pig : 80 %, Rat : 80 %
Characteristics This is a rabbit polyclonal antibody against NLRC4. It was validated on Western Blot and immunohistochemistry.
Purification Affinity Purified
Alternative Name NLRC4 (NLRC4 Antibody Abstract)
Background In C. elegans, Ced4 binds and activates Ced3, an apoptotic initiator caspase, via caspase-associated recruitment domains (CARDs). Human Ced4 homologs include APAF1, NOD1, and NOD2. These proteins have at least 1 N-terminal CARD domain followed by a centrally located nucleotide-binding domain (NBD or NACHT) and a C-terminal regulatory domain, found only in mammals, that contains either WD40 repeats or leucine-rich repeats (LRRs). CARD12 is a member of the Ced4 family and can induce apoptosis.
Molecular Weight 116 kDa
Gene ID 58484
NCBI Accession NP_067032, NM_021209
UniProt Q9NPP4
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 1024 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
Western Blotting (WB) image for anti-NLR Family, CARD Domain Containing 4 (NLRC4) (C-Term) antibody (ABIN184136) WB Suggested Anti-NLRC4 Antibody Titration: 0.2-1 ug/ml
ELISA Titer:
Immunohistochemistry (IHC) image for anti-NLR Family, CARD Domain Containing 4 (NLRC4) (C-Term) antibody (ABIN184136) anti-NLR Family, CARD Domain Containing 4 (NLRC4) (C-Term) antibody (Image 2)
Background publications Clark, Gurney, Abaya et al.: "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. ..." in: Genome research, Vol. 13, Issue 10, pp. 2265-70, 2003 (PubMed).

Catalog No. ABIN184136
$289.00
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