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Interferon Induced with Helicase C Domain 1 (IFIH1) (N-Term) antibody

Details for Product No. ABIN185002
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Antigen
Synonyms MDA5, Hlcd, IDDM19, MDA-5, RLR-2, 9130009C22Rik, Helicard, RGD1560496
Epitope
N-Term
(13), (6), (5), (3), (3), (2), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(61), (34), (1), (1), (1)
Host
Goat
(53), (9), (5)
Clonality
Polyclonal
Methode Type Peptide ELISA
Application
ELISA, Western Blotting (WB), Immunohistochemistry (IHC)
(56), (39), (24), (18), (4), (3), (3), (2), (1)
Pubmed 4 references available
Quantity 100 µg
Options
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Catalog No. ABIN185002
374.27 $
Plus shipping costs $45.00

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Immunogen Peptide with sequence SNGYSTDENFRYL-C, from the N Terminus of the protein sequence according to NP_071451.2.
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Alternative Name MDA5 / IFIH1
Background Synonyms: IFIH1, MDA5, MDA-5, Hlcd, MGC133047, IDDM19, melanoma differentiation associated protein-5, DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide, interferon induced with helicase C domain 1, helicard
Gene ID 64135
NCBI Accession NP_071451.2
Application Notes ELISA: antibody detection limit dilution 1:32000.
Western blot: This antibody has been successfully used in transfected cells as described in the following paper: Sato et al, Arthritis Rheum. 2009 Jul,60(7):2193-200, PMID: 19565506.
IHC: In paraffin embedded Human Pancreas, shows strong cytoplasmic staining of some cells in the islets of Langerhans. Recommended concentration: 10 µg/mL.
Restrictions For Research Use only
Format Liquid
Buffer Supplied at 0.5 mg/mL in Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Minimize freezing and thawing.
Storage -20 °C
Storage Comment Aliquot and store at -20 °C.
Supplier Images
anti-Interferon Induced with Helicase C Domain 1 (IFIH1) (N-Term) antibody ABIN185002 (10µg/ml) staining of paraffin embedded Human Pancreas. Microwaved antigen retrieval with Tris/EDTA buffer pH9, HRP-staining.
Product cited in: Bao, Sinha, Liu et al.: "Identification of human metapneumovirus-induced gene networks in airway epithelial cells by microarray analysis." in: Virology, Vol. 374, Issue 1, pp. 114-27, 2008 (PubMed).

Liao, Bao, Liu et al.: "Role of retinoic acid inducible gene-I in human metapneumovirus-induced cellular signalling." in: The Journal of general virology, Vol. 89, Issue Pt 8, pp. 1978-86, 2008 (PubMed).

Sato, Hoshino, Satoh et al.: "RNA helicase encoded by melanoma differentiation-associated gene 5 is a major autoantigen in patients with clinically amyopathic dermatomyositis: Association with rapidly progressive interstitial lung disease." in: Arthritis and rheumatism, Vol. 60, Issue 7, pp. 2193-200, 2009 (PubMed).

General Kang, Gopalkrishnan, Wu et al.: "mda-5: An interferon-inducible putative RNA helicase with double-stranded RNA-dependent ATPase activity and melanoma growth-suppressive properties." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 2, pp. 637-42, 2002 (PubMed).

Validation Images
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