C3 antibody
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- Target See all C3 Antibodies
- C3 (Complement Component 3 (C3))
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This C3 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunohistochemistry (Frozen Sections) (IHC (fro)), Flow Cytometry (FACS)
- Specificity
- Recognizes 42kD human inactive complement component 3b (iC3b) neoantigen present in blood serum. Cleavage of C3b into iC3b by the protease factor I, in the presence of cofactors, changes the structure and resulting binding properties, preventing binding by complement factor B and properdin. This prevents further progression of the complement pathway, providing another mechanism by which the complement pathway may be regulated. iC3b is thought to play a role in inducing tolerance, binding complement receptor type 3 on antigen presenting cells and stimulating them to produce transforming growth factor beta2 and interleukin-10. It is thought to stimulate B-cells via the CD21 receptor providing a link between the innate and adaptive immune responses. Additionally iC3b acts as an opsonin which is recognized by complement receptor 3 expressed on leukocytes or complement receptor of the immunoglobulin superfamily (CRIg) on Kupffer cells, stimulating phagocytosis of the tagged cells. iC3b levels are often elevated in diseases such as Systemic Lupus Erythematosus and Rheumatoid arthritis.
- Purification
- Protein A purified
- Immunogen
- Purified human iC3b.
- Clone
- 013III-1-16
- Isotype
- IgG2b
- Top Product
- Discover our top product C3 Primary Antibody
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anti-Complement Component 3 (C3) (AA 1000-1326) antibody
C3 Reactivity: Human WB, IHC, IP, ICC Host: Rabbit Polyclonal unconjugated
anti-Complement Component 3 (C3) (AA 1551-1663) antibodyC3 Reactivity: Human, Mouse, Rat WB, ELISA, IHC (fro), IF (p), IHC (p) Host: Rabbit Polyclonal unconjugated
anti-Complement Component 3 (C3) (AA 1534-1644) antibodyC3 Reactivity: Human WB, ELISA, IHC (p) Host: Mouse Monoclonal 5F9 unconjugated
anti-Complement Component 3 (C3) (C-Term) antibodyC3 Reactivity: Human WB, IP, IF, ICC, IHC (p), ISub Host: Rabbit Polyclonal unconjugated
anti-Complement Component 3 (C3) (AA 23-300) antibodyC3 Reactivity: Pig WB, IHC, IP, ICC Host: Rabbit Polyclonal unconjugated
anti-Complement Component 3 (C3) (AA 965-1303) antibodyC3 Reactivity: Mouse WB, IHC, IP, ICC Host: Rabbit Polyclonal unconjugated
anti-Complement Component 3 (C3) (AA 1534-1645) antibodyC3 Reactivity: Human WB, ELISA, IHC, IHC (p) Host: Mouse Monoclonal 5F9 unconjugated
anti-Complement Component 3 (C3) antibodyC3 Reactivity: Mouse WB, IP, FACS, IF, IA Host: Rat Monoclonal 11H9 unconjugated
anti-Complement Component 3 (C3) (AA 966-1313) antibodyC3 Reactivity: Rat WB, IHC, IP, ICC Host: Rabbit Polyclonal unconjugated
anti-Complement Component 3 (C3) (AA 1534-1644) antibodyC3 Reactivity: Human WB, ELISA Host: Mouse Polyclonal unconjugated
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Comment
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Target Species of Antibody: Human
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Borate buffered saline, pH 8.2 - 8.4, 0.02 % sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- 4°C or -20°C, Avoid freeze-thaw cycles.
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- Target
- C3 (Complement Component 3 (C3))
- Alternative Name
- Complement C3 / C3b (C3 Products)
- Pathways
- Complement System, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Regulation of G-Protein Coupled Receptor Protein Signaling
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