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Synuclein, alpha (SNCA) antibody

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Synonyms snca, MGC64356, LOC619283, NACP, alphaSYN, PARK1, PARK4, PD1
(522), (202), (196), (13), (11), (11), (8), (6), (2), (2), (2), (2), (1), (1), (1)
(404), (106), (32), (10), (2), (2)
Clonality (Clone)
Monoclonal ()
(22), (20), (16), (6), (6), (6), (6), (6), (6), (6), (6), (6), (1), (1), (1)
Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), ELISA, Western Blotting (WB)
(378), (188), (123), (94), (76), (67), (24), (21), (18), (17), (10), (6), (2), (1), (1), (1), (1)
Pubmed 7 references available
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Quantity 0.2 mL
Shipping to United States ( )
Availability Will be delivered in 4 to 5 Business Days
Immunogen Purified E. coli produced human alpha-synuclein
Clone 4D6
Isotype IgG1
Specificity Reacts well with alpha-synuclein in Western blots and frozen and formalin-fixed/paraffin-embedded tissue sections. Recognizes human alpha-synuclein. Synuclein-alpha is the major component of Lewy bodies and Lewy neuritis in sporadic PD. dementia with Lewy Bodies and Lewy Body variant of AD. Lewy bodies are composed of truncated and phosphorylated intermediate neurofilament proteins, alpha synuclein, ubiquitin and associated enzymes. The synuclein phosphoproteins (15-20 kDa) are small highly conserved proteins in vertebrates. The synuclein family includes alpha and beta synucleins and loosely related gamma-synuclein and synoretin. The expression is abundant in neurons and typically localized at presynaptic terminals.
Characteristics MAb to Synuclein Alpha, Monoclonal antibody to Human Synuclein alpha, Tissue culture supernatant
Purification Protein A column Chromatography. Cell culture
Alternative Name Synuclein alpha (SNCA Antibody Abstract)
Application Notes Western/Dot blot (1:100 - 1:10.000) ELISA Immunohistochemistry: (1:100 - 1:1.000) frozen and formalin-fixed paraffin-embedded tissues (No formic acid, enzyme or HIER required). Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.
Restrictions For Research Use only
Format Liquid
Buffer PBS.
Preservative Without preservative
Handling Advice Avoid multiple freeze/thaw cycles.
Centrifuge product if not completely clear after standing at room temperature.
Prepare working dilution only prior to immediate use.
Storage -20 °C
Storage Comment Store at -20 °C.
Background publications Trojanowski, Lee: "\' of proteins. A comprehensive hypothetical mechanism underlying Alzheimer's disease and other neurodegenerative disorders." in: Annals of the New York Academy of Sciences, Vol. 924, pp. 62-7, 2001 (PubMed).

Conway, Lee, Rochet et al.: "Accelerated oligomerization by Parkinson's disease linked alpha-synuclein mutants." in: Annals of the New York Academy of Sciences, Vol. 920, pp. 42-5, 2001 (PubMed).

Kahle, Neumann, Ozmen et al.: "Physiology and pathophysiology of alpha-synuclein. Cell culture and transgenic animal models based on a Parkinson's disease-associated protein." in: Annals of the New York Academy of Sciences, Vol. 920, pp. 33-41, 2001 (PubMed).

Polymeropoulos: "Genetics of Parkinson's disease." in: Annals of the New York Academy of Sciences, Vol. 920, pp. 28-32, 2001 (PubMed).

Spillantini, Goedert: "The alpha-synucleinopathies: Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy." in: Annals of the New York Academy of Sciences, Vol. 920, pp. 16-27, 2001 (PubMed).

McKeith: "Clinical Lewy body syndromes." in: Annals of the New York Academy of Sciences, Vol. 920, pp. 1-8, 2001 (PubMed).

Braak, Braak: "Pathoanatomy of Parkinson's disease." in: Journal of neurology, Vol. 247 Suppl 2, pp. II3-10, 2000 (PubMed).

Catalog No. ABIN236423
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