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PD-1 antibody

Name: PD-1 antibody
SKU: ABIN2665479
Availability: OutOfStock

PDCD1 Reactivity: Mouse FACS, ELISA Host: Rat Monoclonal RMP1-14 unconjugated

FACS

1 image

Catalog No. ABIN2665479

Datasheet as PDF

Target See all PD-1 (PDCD1) Antibodies

PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))
Reactivity
149

80

26

5

3

1
Mouse
Host
85

69

31

13

3

2

2

2

1
Rat
Compatible Secondaries
Clonality
142

60

5
Monoclonal
Conjugate
112

13

12

10

5

4

3

3

3

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
This PD-1 antibody is un-conjugated
Application
131

67

51

49

37

20

13

13

13

11

10

9

9

7

5

4

4

4

4

3

2

1

1

1

1

1
Flow Cytometry (FACS), ELISA

Purification

The antibody was purified by affinity chromatography.

Clone

RMP1-14

Isotype

IgG2a kappa

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Application Notes

Optimal working dilution should be determined by the investigator.

Restrictions

For Research Use only
Concentration

0.5 mg/mL

Buffer

Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Preservative

Sodium azide

Precaution of Use

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice

Do not freeze.

Storage

4 °C

Storage Comment

The antibody solution should be stored undiluted between 2°C and 8°C.
Target

PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))

Alternative Name

CD279 (PDCD1 Products)

Background

CD279 is a 50-55 kD immunoglobulin superfamily member, also known as programmed death-1 (PD-1). PD-1 is expressed on a subset of CD4-CD8- thymocytes, and on activated T and B cells. PD-1 is thought to be involved in lymphocyte clonal selection and peripheral tolerance. The PD-1 ligands, PD-L1 (also known as B7-H1) and PD-L2 (B7-DC), are members of the B7 immunoglobulin superfamily. The RMP1-14 antibody has been reported to block the binding of PD-1 to its ligands (B7-H1 and B7-DC) and to inhibit T cell proliferation and cytokine production costimulated by macrophages (but not by dendritic cells and B cells).

Pathways

Cancer Immune Checkpoints