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Details for Product No. ABIN302240

Intercellular Adhesion Molecule 1 (ICAM1) antibody

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Antigen
Synonyms BB2, CD54, P3.58, Icam-1, Ly-47, MALA-2, ICAM1, ICAM-1, ICAM
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Pubmed 5 references available
Catalog no. ABIN302240
Quantity 0.1 mg
Price
297.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen Raji cells and spleen cells fused with NS1 cells
Clone 1H4
Isotype IgG2b
Characteristics Synonyms: ICAM-1, Intercellular adhesion molecule 1, Major Group Rhinovirus Receptor
Purification Protein A Affinity Chromatography
Alternative Name CD54 / ICAM1
Background CD54 (ICAM-1) is a 90 kD member of the C2 subset of immunoglobulin superfamily. It is atransmembrane molecule with 7 potential N-glycosylated sites, expressed on restingmonocytes and endothelial cells and can be upregulated on many other cells, e. g. withlymphokines, on B- and T-lymphocytes, thymocytes, dendritic cells and also onkeratinocytes, chondrocytes, as well as epithelial cells. CD54 mediates cell adhesion bybinding to integrins CD11a/CD18 (LFA-1) and to CD11b/CD18 (Mac-1). The interaction of CD54with LFA-1 enhances antigen-specific T-cell activation.
UniProt P05362
Application Notes Flow Cytometry. Western blot. Immunohistochemistry (paraffin sections): 10-20 ug/ml (Prolonged fixation in bufferedformalin can destroy the epitope, hight temperature antigen unmasking technique isrequired). Immunohistochemistry (frozen sections): 5-20 ug/ml. Immunocytochemistry. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer Azide free PBS preserved by filter sterilization, pH~7.4
Preservative Azide free
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoidrepeated freezing and thawing. Shelf life: one year from despatch.
Expiry Date 12 months
Background publications Ockenhouse, Betageri, Springer et al.: "Plasmodium falciparum-infected erythrocytes bind ICAM-1 at a site distinct from LFA-1, Mac-1, and human rhinovirus." in: Cell, Vol. 68, Issue 1, pp. 63-9, 1992 (PubMed).

Springer: "Adhesion receptors of the immune system." in: Nature, Vol. 346, Issue 6283, pp. 425-34, 1990 (PubMed).

Boyd, Dunn, Fecondo et al.: "Regulation of expression of a human intercellular adhesion molecule (ICAM-1) during lymphohematopoietic differentiation." in: Blood, Vol. 73, Issue 7, pp. 1896-903, 1989 (PubMed).

Boyd, Wawryk, Burns et al.: "Intercellular adhesion molecule 1 (ICAM-1) has a central role in cell-cell contact-mediated immune mechanisms." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 85, Issue 9, pp. 3095-9, 1988 (PubMed).

Williams, Chaudhry, Goodfellow et al.: "Interactions of decay-accelerating factor (DAF) with haemagglutinating human enteroviruses: utilizing variation in primate DAF to map virus binding sites." in: The Journal of general virology, Vol. 85, Issue Pt 3, pp. 731-8, 2004 (PubMed).

Alternatives for antigen "Intercellular Adhesion Molecule 1 (ICAM1)", type "Antibodies"
Hosts (323), (219), (70), (5), (5), (3)
Reactivities (497), (144), (95), (47), (34), (18), (17), (3), (1), (1)
Applications (371), (226), (141), (122), (121), (79), (73), (66), (42), (41), (40), (31), (13), (7), (6), (4), (2), (2), (1), (1), (1), (1), (1), (1)
Conjugates (68), (55), (41), (10), (10), (9), (9), (8), (8), (8), (8), (8), (8), (8), (4), (4), (4), (4), (2), (2), (1), (1), (1)
Epitopes (31), (11), (6), (5), (3), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1)
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