Lysosomal-Associated Membrane Protein 1 (LAMP1) (Center) antibody

Details for Product No. ABIN303277
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Antigen
Synonyms AI196048, CD107a, Lamp-1, LAMPA, LGP120, LEP100
Epitope
Center
(14), (12), (7), (6), (5), (4), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(132), (69), (58), (7), (7), (3), (3), (2)
Host
Rabbit
(92), (73), (31), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(22), (15), (15), (10), (3), (3), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(110), (87), (43), (39), (38), (33), (28), (21), (19), (10), (1), (1)
Pubmed 5 references available
Quantity 50 µg
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Catalog No. ABIN303277
500.50 $
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Immunogen Synthetic Peptide corresponding to 15 amino acid peptide from near the center of Human LAMP-1.
Specificity Recognizes Lysosome-associated Membrane Glycoprotein 1 (LAMP1).
Purification Immunoaffinity Chromatography.
Alternative Name CD107a / LAMP1
Background CD107a (lysosome-associated membrane protein-1, LAMP-1), together with LAMP-2, is a major constituent of lysosomal membrane, 1-2% of total CD107a is found also on the plasma membrane. The LAMP proteins are involved in lysosome biogenesis and are required for fusion of lysosomes with phagosomes. Increased CD107a immunoreactivity is observed in neurones, and in glial cells surrounding senile plaques in Alzheimers disease cases and is localized mainly in medullary epithelial cells, single macrophages and lymphocytes in acute thymic involution. CD107a is a good marker of mast cell activation.
Alternate names: CD107 Antigen-like Family Member A, LAMP-1, LAMPA, LGP120, Lysosome-associated membrane glycoprotein 1
Gene ID 3916
NCBI Accession NP_005552
UniProt P11279
Research Area CD Antigens, Surface Receptors of Immune Cells
Application Notes Western Blot. Immunofluorescence. Immunohistochemistry on Paraffin Sections (5 µg/ml). This LAMP1 antibody was validated for use in immunohistochemistry on a panel of 21formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigenretrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides wereincubated with biotinylated secondary antibody, followed by alkalinephosphatase-streptavidin and chromogen. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS containing 0.02% Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at-20°C for longer. Dilute only prior to immediate use.
Expiry Date 12 months
Supplier Images
anti-Lysosomal-Associated Membrane Protein 1 (LAMP1) (Center) antibody anti-Lysosomal-Associated Membrane Protein 1 (LAMP1) (Center) antibody
anti-Lysosomal-Associated Membrane Protein 1 (LAMP1) (Center) antibody (2) anti-Lysosomal-Associated Membrane Protein 1 (LAMP1) (Center) antibody (Image 2)
anti-Lysosomal-Associated Membrane Protein 1 (LAMP1) (Center) antibody (3) anti-Lysosomal-Associated Membrane Protein 1 (LAMP1) (Center) antibody (Image 3)
Background publications Grützkau, Smorodchenko, Lippert et al.: "LAMP-1 and LAMP-2, but not LAMP-3, are reliable markers for activation-induced secretion of human mast cells." in: Cytometry. Part A : the journal of the International Society for Analytical Cytology, Vol. 61, Issue 1, pp. 62-8, 2004 (PubMed).

Barrachina, Maes, Buesa et al.: "Lysosome-associated membrane protein 1 (LAMP-1) in Alzheimer's disease." in: Neuropathology and applied neurobiology, Vol. 32, Issue 5, pp. 505-16, 2006 (PubMed).

Eskelinen: "Roles of LAMP-1 and LAMP-2 in lysosome biogenesis and autophagy." in: Molecular aspects of medicine, Vol. 27, Issue 5-6, pp. 495-502, 2006 (PubMed).

Sarafian, Marinova: "Lysosomal membrane-associated glycoproteins are differentially expressed in acute and chronic human thymic involution." in: Acta biologica Hungarica, Vol. 57, Issue 3, pp. 315-22, 2006 (PubMed).

Huynh, Eskelinen, Scott et al.: "LAMP proteins are required for fusion of lysosomes with phagosomes." in: The EMBO journal, Vol. 26, Issue 2, pp. 313-24, 2007 (PubMed).

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