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Lipopolysaccharide Binding Protein (LBP) antibody

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Synonyms LBP, BmCTL21, 1, Lbp, MEF, Mfe, Mfe1, Pbe, Pbfe, perMFE-1, 1300002P22Rik, HD, L-PBE, LBFP, MFP, MFP1, PBFE, BPIFD2, LPSBP, Bpifd2, Ly88
(54), (37), (15), (7), (5), (4), (1), (1), (1), (1), (1)
(56), (22), (14), (4)
Clonality (Clone)
Monoclonal ()
(4), (3)
Functional Studies (Func), ELISA
(61), (56), (20), (13), (12), (9), (8), (7), (3), (3), (3), (3), (2), (2), (2), (1), (1), (1)
Pubmed 4 references available
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Quantity 0.1 mg
Shipping to United States ( )
Availability Will be delivered in 4 to 5 Business Days
Immunogen LBP knock out mouse immunized with immunoaffinity purified recombinant human LBP
Clone BiG 412
Isotype IgG1
Purification Protein G purified
Alternative Name Lipopolysaccharide (LPS)-Binding Protein (LBP) (LBP Antibody Abstract)
Background LPS binding protein (LBP) is an approximately 60 kDa acute phase protein that is produced by hepatocytes. This protein strongly binds to LPS and has been shown to play an important role in the handling of LPS by the host. A number of functions of LBP have been reported. First, LBP transfers LPS to the LPS receptor CD14 on mononuclear phagocytes, leading to a 100-1,000-fold increased sensitivity of the cells to LPS. Furthermore, LBP can enhance the response of CD14 negative cells by acceleration of LPS binding to soluble CD14, a complex that stimulates these cells. Next, LBP transfers LPS into High Density Lipoprotein (HDL), which effectively neutralizes its biological potency. LBP was demonstrated to protect mice from septic shock caused by LPS or gram negative bacteria
Research Area Apoptosis/Necrosis, Immunology, Inflammation
Pathways TLR Signaling
Application Notes inhibition of LPS binding to membrane bound CD14, inhibition titre 1:1000. Binding titre at human LBP- ELISA: 1:50.000, cross reacting with bovine LBP.
Restrictions For Research Use only
Format Lyophilized
Concentration 2.0 mg/ml (determined by mouse IgG-ELISA) before lyophilization
Buffer with NaN3
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Product cited in: Muansson, Kjaell, Pellett et al.: "Role of the lipopolysaccharide-CD14 complex for the activity of hemolysin from uropathogenic Escherichia coli." in: Infection and immunity, Vol. 75, Issue 2, pp. 997-1004, 2007 (PubMed).

Kato, Ogasawara, Homma et al.: "Lipopolysaccharide-binding protein critically regulates lipopolysaccharide-induced IFN-beta signaling pathway in human monocytes." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 172, Issue 10, pp. 6185-94, 2004 (PubMed).

Berner, Fürll, Stelter et al.: "Elevated levels of lipopolysaccharide-binding protein and soluble CD14 in plasma in neonatal early-onset sepsis." in: Clinical and diagnostic laboratory immunology, Vol. 9, Issue 2, pp. 440-5, 2002 (PubMed).

Vidal, Labéta, Schiffrin et al.: "Soluble CD14 in human breast milk and its role in innate immune responses." in: Acta odontologica Scandinavica, Vol. 59, Issue 5, pp. 330-4, 2001 (PubMed).

Catalog No. ABIN343177
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