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Details for Product No. ABIN350137

Calcium Channel, Voltage-Dependent, L Type, alpha 1C Subunit (CACNA1C) (Cytoplasmic Domain) antibody

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Antigen
Synonyms CACH2, CACN2, CACNL1A1, CCHL1A1, CaV1.2, LQT8, TS, Cav1.2, Cchl1a1, MBC, MELC-CC, RATIVS302, CHCACHA1C, CAV1.2, isl, C-LTCC, ICA, cav1.2, ca(v)1.2
Epitope
»Alternatives Cytoplasmic Domain
Reactivity
»Alternatives Human, Mouse (Murine), Rat (Rattus), Rabbit
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN350137
Quantity 500 µg
Price
454.67 $   Plus shipping costs $45.00
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Product details

Target Details Application Details Handling References Alternatives back to top
Immunogen A synthetic peptide from a cytoplasmic domain of human CACNA1C (Cav1.2) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen shares 96% identity with mouse, rat and rabbit sequence.
Isotype IgG
Specificity Appears to be specific for CACNA1C.
Purity IgG

Target Details

Application Details Handling References Alternatives back to top
Alternative Name CACNA1C (Cav1.2)
Background Function: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1C gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1C subunit play an important role in excitation-contraction coupling in the heart. The various isoforms display marked differences in the sensitivity to DHP compounds.
Subcellular location: Membrane, Multi-pass membrane protein.
Tissue specificity: Expressed in brain, heart, jejunum, ovary, pancreatic beta-cells and vascular smooth muscle. Overall expression is reduced in atherosclerotic vascular smooth muscle. Also known as: CACH2, CACN2, CACNL1A1, CCHL1A1, Voltage-gated calcium channel subunit alpha Cav1.2, Calcium channel, L type, alpha-1 polypeptide, cardiac muscle, Voltage dependent L-type calcium channel subunit alpha-1C.
UniProt Q13936

Application Details

Target Details Handling References Alternatives back to top
Application Notes IHC, WB. A concentration of 10-50 µg/ml is recommended. The optimal concentration should be determined by the end user. Not tested in other applications.
Restrictions For Research Use only

Handling

Target Details Application Details References Alternatives back to top
Format Lyophilized
Storage -20 °C

References

Target Details Application Details Handling Alternatives back to top
Soldatov, Bouron, Reuter: "Different voltage-dependent inhibition by dihydropyridines of human Ca2+ channel splice variants." in: The Journal of biological chemistry, Vol. 270, Issue 18, pp. 10540-3, 1995 (PubMed).

Schultz, Mikala, Yatani et al.: "Cloning, chromosomal localization, and functional expression of the alpha 1 subunit of the L-type voltage-dependent calcium channel from normal human heart." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 90, Issue 13, pp. 6228-32, 1993 (PubMed).

Zuehlke, Bouron, Soldatov et al.: "Ca2+ channel sensitivity towards the blocker isradipine is affected by alternative splicing of the human alpha1C subunit gene." in: FEBS letters, Vol. 427, Issue 2, pp. 220-4, 1998 (PubMed).

Scherer, Muzny, Buhay et al.: "The finished DNA sequence of human chromosome 12." in: Nature, Vol. 440, Issue 7082, pp. 346-51, 2006 (PubMed).

Antzelevitch, Pollevick, Cordeiro et al.: "Loss-of-function mutations in the cardiac calcium channel underlie a new clinical entity characterized by ST-segment elevation, short QT intervals, and sudden cardiac death." in: Circulation, Vol. 115, Issue 4, pp. 442-9, 2007 (PubMed).

Alternatives

Target Details Application Details Handling References back to top
Alternatives for antigen "Calcium Channel, Voltage-Dependent, L Type, alpha 1C Subunit (CACNA1C)", type "Antibodies"
Hosts (107), (25), (7)
Reactivities (73), (37), (37), (24), (22), (16), (16), (4), (4), (4), (4), (4), (4), (4), (4), (3)
Applications (51), (24), (21), (20), (14), (12), (9), (9), (8), (4), (3), (1), (1), (1)
Conjugates (17), (14), (4), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (13), (8), (8), (3), (3), (2), (2), (2), (2), (2), (1), (1)
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