CACNA1C Products
(Calcium Channel, Voltage-Dependent, L Type, alpha 1C Subunit (CACNA1C))
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This gene encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. The protein encoded by this gene binds to and is inhibited by dihydropyridine. Alternative splicing results in many transcript variants encoding different proteins. Some of the predicted proteins may not produce functional ion channel subunits. [provided by RefSeq, Oct 2012].
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Featured CACNA1C Categories
CACNA1C Antibodies
High quality antibodies with extensive validation data.
CACNA1C ELISA Kits
Reliable ELISA kits for a wide range of species.
CACNA1C Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended CACNA1C Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Rabbit
Application
WB, IHC, IP, IF, ICC, AA
Validations
- (7)
Cat. No.
ABIN361759
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Rabbit
Application
WB, IHC, IP, IF, ICC, AA
Validations
- (7)
Cat. No.
ABIN2485658
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Rabbit
Application
WB, IHC, IP, IF, ICC, AA
Validations
- (7)
Cat. No.
ABIN2485657
Quantity
100 μg
Datasheet
Datasheet
Recommended CACNA1C ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6954269
Quantity
96 tests
Datasheet
Datasheet
Recommended CACNA1C Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1347816
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN3090466
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN3090465
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our CACNA1C products
: "What constitutes the fat signal detected by MRI in the spine of patients with ankylosing spondylitis? A prospective study based on biopsies obtained during planned spinal osteotomy to correct ..." in: Annals of the rheumatic diseases, Vol. 78, Issue 9, pp. 1220-1225, (2019) (PubMed).: "Loss of Protein Arginine Methyltransferase 8 Alters Synapse Composition and Function, Resulting in Behavioral Defects." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 37, Issue 36, pp. 8655-8666, (2017) (PubMed).
: "Myoscape controls cardiac calcium cycling and contractility via regulation of L-type calcium channel surface expression." in: Nature communications, Vol. 7, pp. 11317, (2016) (PubMed).
: "Calcium current homeostasis and synaptic deficits in hippocampal neurons from Kelch-like 1 knockout mice." in: Frontiers in cellular neuroscience, Vol. 8, pp. 444, (2015) (PubMed).
: "Costimulation of AMPA and metabotropic glutamate receptors underlies phospholipase C activation by glutamate in hippocampus." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 35, Issue 16, pp. 6401-12, (2015) (PubMed).
: "Cultured Cells from the Human Oocyte Cumulus Niche Are Efficient Feeders to Propagate Pluripotent Stem Cells." in: Stem cells and development, (2015) (PubMed).
: "Vitis labrusca extract effects on cellular dynamics and redox modulations in a SH-SY5Y neuronal cell model: a similar role to lithium." in: Neurochemistry international, Vol. 79, pp. 12-9, (2015) (PubMed).
: "Potentiation of high voltage-activated calcium channels by 4-aminopyridine depends on subunit composition." in: Molecular pharmacology, Vol. 86, Issue 6, pp. 760-72, (2014) (PubMed).
: "Surface L-type Ca2+ channel expression levels are increased in aged hippocampus." in: Aging cell, Vol. 13, Issue 1, pp. 111-20, (2014) (PubMed).
: "Protein kinase C-dependent activation of CaV1.2 channels selectively controls human TH2-lymphocyte functions." in: The Journal of allergy and clinical immunology, Vol. 133, Issue 4, pp. 1175-83, (2014) (PubMed).
Synonyms and alternative names related to CACNA1C
calcium voltage-gated channel subunit alpha1 C (CACNA1C), calcium channel, voltage-dependent, L type, alpha 1C subunit (Cacna1c), calcium voltage-gated channel subunit alpha1 C (Cacna1c), calcium channel, voltage-dependent, L type, alpha 1C subunit (cacna1c), voltage-dependent L-type calcium channel subunit alpha-1C (LOC100442085), calcium channel, voltage-dependent, L type, alpha 1C subunit S homeolog (cacna1c.S), Red blood cell count (RBC), RNA, 7SL, cytoplasmic 263, pseudogene (RN7SL263P), BCR, C-LTCC, ca(v)1.2, CACH2, CACN2, CACNL1A1, CaV1.2, Cav1.2, cav1.2, CAV1.2, CCHL1A1, Cchl1a1, CHCACHA1C, ICA, isl, LQT8, MBC, MELC-CC, RATIVS302, rbc, TSProtein level used designations for CACNA1C
- DHPR, alpha-1 subunit
- calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle
- calcium channel, cardic dihydropyridine-sensitive, alpha-1 subunit
- voltage-dependent L-type calcium channel subunit alpha-1C
- voltage-gated L-type calcium channel Cav1.2 alpha 1 subunit, splice variant 10*
- L-type Cav1.2
- brain class C
- calcium channel voltage-dependent alpha1c subunit
- neuronal voltage-gated calcium channel alpha 1C subunit
- skeletal muscle-specific calcium channel
- voltage-gated calcium channel subunit alpha Cav1.2
- L-type calcium channel alpha-1 subunit
- RBC
- calcium channel, voltage-dependent, alpha 1C subunit
- ZfCav1.2
- island beat
- L-type voltage-gated calcium channel alpha1C subunit ChCaChA1C
- L-type Ca channel alpha 1 subunit
- L-type calcium channel CaV1.2
- atrium L-type calcium channel
- L-type voltage-dependent calcium channel alpha-1 subunit
- calcium channel, voltage-dependent, L type, alpha 1C subunit
- voltage-dependent L-type calcium channel subunit alpha-1C-like
- calcium channel voltage-dependent L type Cav1.2, alpha 1c subunit
- CaCB receptor
- smooth muscle calcium channel blocker
- voltage-gated calcium channel alpha 1C subunit
- breakpoint cluster region protein
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