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Details for Product No. ABIN350141

Calcium Channel, Voltage-Dependent, R Type, alpha 1E Subunit (CACNA1E) (Cytoplasmic Domain), (AA 1700-1750) antibody

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Antigen
Synonyms BII, CACH6, Cav2.3, CACNL1A6, CACHA1E, Cach6, Cchra1, alpha1E, Cacnl1a6, A430040I15, caV2.3, CACNA1E
Epitope
»Alternatives Cytoplasmic Domain, AA 1700-1750
Reactivity
»Alternatives Rat (Rattus)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 4 references available
Catalog no. ABIN350141
Quantity 100 µL
Price
454.67 $   Plus shipping costs $45.00
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Product details

Target Details Application Details Handling References Alternatives back to top
Immunogen A synthetic peptide from c-terminal region of rat TRPC6 conjugated to an immunogenic carrier protein was used as the immunogen.
Specificity Specific for TRPC6.
Purity IgG

Target Details

Application Details Handling References Alternatives back to top
Alternative Name CACNA1E (Cav2.3)
Background Function: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by nickel, and partially by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to dihydropyridines (DHP), omega-conotoxin-GVIA (omega-CTx-GVIA), and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels contaning alpha-1E subunit could be involved in the modulation of firing patterns of neurons which is important for information processing.
Subcellular location: Membrane, Multi-pass membrane protein.
Tissue specificity: Expressed in neuronal tissues and in kidney. Also known as: Voltage-dependent R-type calcium channel subunit alpha-1E, Voltage-gated calcium channel subunit alpha Cav2.3, Calcium channel, L type, alpha-1 polypeptide, Brain calcium channel II, CACH6, CACNL1A6.
UniProt Q99N76
Research Area Signaling

Application Details

Target Details Handling References Alternatives back to top
Application Notes A concentration of 10-50 µg/mL is recommended.
The optimal concentration should be determined by the end user.
Not tested in other applications.
Restrictions For Research Use only

Handling

Target Details Application Details References Alternatives back to top
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage -20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20 °C for long term storage and refrigerated at 2-8 °C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability.
Expiry Date 12 months

References

Target Details Application Details Handling Alternatives back to top
Schneider, Wei, Olcese et al.: "Molecular analysis and functional expression of the human type E neuronal Ca2+ channel alpha 1 subunit." in: Receptors & channels, Vol. 2, Issue 4, pp. 255-70, 1995 (PubMed).

Williams, Marubio, Deal et al.: "Structure and functional characterization of neuronal alpha 1E calcium channel subtypes." in: The Journal of biological chemistry, Vol. 269, Issue 35, pp. 22347-57, 1994 (PubMed).

Suzuki, Delgado-Escueta, Aguan et al.: "Mutations in EFHC1 cause juvenile myoclonic epilepsy." in: Nature genetics, Vol. 36, Issue 8, pp. 842-9, 2004 (PubMed).

Gregory, Barlow, McLay et al.: "The DNA sequence and biological annotation of human chromosome 1." in: Nature, Vol. 441, Issue 7091, pp. 315-21, 2006 (PubMed).

Alternatives

Target Details Application Details Handling References back to top
Alternatives for antigen "Calcium Channel, Voltage-Dependent, R Type, alpha 1E Subunit (CACNA1E)", type "Antibodies"
Hosts (26)
Reactivities (25), (21), (19), (17), (17), (17), (17)
Applications (15), (12), (10), (5), (3), (2), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (1), (1), (1), (1)
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