Lysine (K)-Specific Demethylase 3B (KDM3B) (N-Term) antibody

Details for Product No. ABIN356557
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Antigen
Synonyms KDM3B, JMJD1B, 5830462I21Rik, JHDM2B, Jmjd1b, mKIAA1082, 5qNCA, C5orf7, NET22
Epitope
N-Term
(10), (7), (7), (5), (2), (2), (2), (2), (2), (2), (1), (1), (1)
Reactivity
Human
(63), (27), (24), (14), (14), (12), (2), (2), (2)
Host
Rabbit
(60), (3)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
(43), (26), (10), (9), (9), (7), (5), (4), (4), (4), (2), (2)
Pubmed 5 references available
Quantity 0.4 mL
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Catalog No. ABIN356557
357.50 $
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Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human JMJD1B.
Isotype Ig
Specificity This antibody will recognize JMJD1B (N-term).
Purification Protein A Chromatography, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name JMJD1B / KDM3B
Background Covalent modification of histones plays critical role in regulating chromatin structure and transcription. While most covalent histone modifications are reversible, only recently has it been established that methyl groups are subject to enzymatic removal from histones. A family of novel JmjC domain-containing histone demethylation (JHDM) enzymes have been identified that perform this specific function. Histone demethylation by JHDM proteins requires cofactors Fe(II) and alpha-ketoglutarate. Family members include JHDM1 (demethylating histone 3 at lysine 36), and JHDM2A as well as JMJD2CH3K9 (both of which demethylate histone 3 at lysine 9). Contributions of histone demethylase activity to tumor development, decreases in cell proliferation, and hormone-dependent transcriptional activation have been observed.Synonyms: 5qNCA, C5orf7, JHDM2B, JmjC domain-containing histone demethylation protein 2B, Jumonji domain-containing protein 1B, KIAA1082, Lysine-specific demethylase 3B, Nuclear protein 5qNCA
Gene ID 51780, 9606
UniProt Q7LBC6
Application Notes ELISA: 1/1,000. Western Blot: 1/250-1/500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
Supplier Images
anti-Lysine (K)-Specific Demethylase 3B (KDM3B) (N-Term) antibody anti-Lysine (K)-Specific Demethylase 3B (KDM3B) (N-Term) antibody
Background publications Dias Neto, Correa, Verjovski-Almeida et al.: "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 7, pp. 3491-6, 2000 (PubMed).

Lai, Godley, Fernald et al.: "cDNA cloning and genomic structure of three genes localized to human chromosome band 5q31 encoding potential nuclear proteins." in: Genomics, Vol. 70, Issue 1, pp. 123-30, 2001 (PubMed).

Lai, Godley, Joslin et al.: "Transcript map and comparative analysis of the 1.5-Mb commonly deleted segment of human 5q31 in malignant myeloid diseases with a del(5q)." in: Genomics, Vol. 71, Issue 2, pp. 235-45, 2001 (PubMed).

Hu, Gomes, Horrigan et al.: "A novel nuclear protein, 5qNCA (LOC51780) is a candidate for the myeloid leukemia tumor suppressor gene on chromosome 5 band q31." in: Oncogene, Vol. 20, Issue 47, pp. 6946-54, 2001 (PubMed).

Katoh, Katoh: "Identification and characterization of TRIP8 gene in silico." in: International journal of molecular medicine, Vol. 12, Issue 5, pp. 817-21, 2003 (PubMed).

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