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RuvB-Like 2 (E. Coli) (RUVBL2) (C-Term) antibody

Details for Product No. ABIN357238, Supplier: Log in to see
Antigen
  • MGC52995
  • rvb2
  • ecp51
  • tip48
  • cgi-46
  • reptin
  • tip49b
  • xReptin
  • MGC69398
  • RUVBL2
  • ECP51
  • INO80J
  • REPTIN
  • RVB2
  • TIH2
  • TIP48
  • TIP49B
  • wu:fi25f01
  • zreptin
  • mp47
  • p47
Alternatives
anti-Human RuvB-Like 2 (E. Coli) antibody for Immunohistochemistry
Epitope
C-Term
16
9
6
3
3
2
2
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
62
17
16
9
3
3
2
2
1
Host
Rabbit
46
16
Clonality
Polyclonal
Conjugate
Un-conjugated
2
2
2
2
2
2
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
51
22
21
16
11
8
4
1
1
Supplier
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Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human RUVBL2.
Isotype Ig
Specificity This antibody detects Reptin/TIP49B/RUVB2 at C-term.
Purification Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
Alternative Name RUVBL2 / TIP49B (RUVBL2 Antibody Abstract)
Background This gene encodes the second human homologue of the bacterial RuvB gene. Bacterial RuvB protein is a DNA helicase essential for homologous recombination and DNA double-strand break repair. Functional analysis showed that this gene product has both ATPase and DNA helicase activities. This gene is physically linked to the CGB/LHB gene cluster on chromosome 19q13.3, and is very close (55 nt) to the LHB gene, in the opposite orientation.Synonyms: 48 kDa TATA box-binding protein-interacting protein, 48 kDa TBP-interacting protein, 51 kDa erythrocyte cytosolic protein, CGI-46, ECP-51, INO80 complex subunit J, INO80J, Repressing pontin 52, Reptin 52, RuvB-like 2, TAP54-beta, TIP48, TIP49B, TIP60-associated protein 54-beta
Molecular Weight 51157 Da
Gene ID 10856, 9606
UniProt Q9Y230
Pathways Telomere Maintenance
Application Notes ELISA 1: 1,000. Western blot 1: 250 - 1: 500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.
Supplier Images
 image for anti-RuvB-Like 2 (E. Coli) (RUVBL2) (C-Term) antibody (ABIN357238) anti-RuvB-Like 2 (E. Coli) (RUVBL2) (C-Term) antibody
Background publications Bauer, Chauvet, Huber et al.: "Pontin52 and reptin52 function as antagonistic regulators of beta-catenin signalling activity." in: The EMBO journal, Vol. 19, Issue 22, pp. 6121-30, 2000 (PubMed).

Parfait, Giovangrandi, Asheuer et al.: "Human TIP49b/RUVBL2 gene: genomic structure, expression pattern, physical link to the human CGB/LHB gene cluster on chromosome 19q13.3." in: Annales de génétique, Vol. 43, Issue 2, pp. 69-74, 2000 (PubMed).

Wood, McMahon, Cole: "An ATPase/helicase complex is an essential cofactor for oncogenic transformation by c-Myc." in: Molecular cell, Vol. 5, Issue 2, pp. 321-30, 2000 (PubMed).

Salzer, Kubicek, Prohaska: "Isolation, molecular characterization, and tissue-specific expression of ECP-51 and ECP-54 (TIP49), two homologous, interacting erythroid cytosolic proteins." in: Biochimica et biophysica acta, Vol. 1446, Issue 3, pp. 365-70, 1999 (PubMed).

Kanemaki, Kurokawa, Matsu-ura et al.: "TIP49b, a new RuvB-like DNA helicase, is included in a complex together with another RuvB-like DNA helicase, TIP49a." in: The Journal of biological chemistry, Vol. 274, Issue 32, pp. 22437-44, 1999 (PubMed).