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RuvB-Like 2 (E. Coli) (RUVBL2) (C-Term) antibody

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Synonyms MGC52995, rvb2, ecp51, tip48, cgi-46, reptin, tip49b, xReptin, MGC69398, RUVBL2, ECP51, INO80J, REPTIN, RVB2, TIH2, TIP48, TIP49B, wu:fi25f01, zreptin, mp47, p47
(16), (9), (6), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1)
Human, Mouse (Murine)
(65), (17), (16), (9), (3), (3), (2), (2), (1)
(49), (16)
(2), (2), (2), (2), (2), (2)
Enzyme Immunoassay (EIA), Western Blotting (WB)
(54), (23), (22), (17), (12), (8), (4), (2), (1)
Pubmed 5 references available
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Quantity 0.4 mL
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Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human RUVBL2.
Isotype Ig
Specificity This antibody detects Reptin/TIP49B/RUVB2 at C-term.
Purification Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
Alternative Name RUVBL2 / TIP49B (RUVBL2 Antibody Abstract)
Background This gene encodes the second human homologue of the bacterial RuvB gene. Bacterial RuvB protein is a DNA helicase essential for homologous recombination and DNA double-strand break repair. Functional analysis showed that this gene product has both ATPase and DNA helicase activities. This gene is physically linked to the CGB/LHB gene cluster on chromosome 19q13.3, and is very close (55 nt) to the LHB gene, in the opposite orientation.Synonyms: 48 kDa TATA box-binding protein-interacting protein, 48 kDa TBP-interacting protein, 51 kDa erythrocyte cytosolic protein, CGI-46, ECP-51, INO80 complex subunit J, INO80J, Repressing pontin 52, Reptin 52, RuvB-like 2, TAP54-beta, TIP48, TIP49B, TIP60-associated protein 54-beta
Molecular Weight 51157 Da
Gene ID 10856, 9606
UniProt Q9Y230
Pathways Telomere Maintenance
Application Notes ELISA 1: 1,000. Western blot 1: 250 - 1: 500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.
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 image for anti-RuvB-Like 2 (E. Coli) (RUVBL2) (C-Term) antibody (ABIN357238) anti-RuvB-Like 2 (E. Coli) (RUVBL2) (C-Term) antibody
Background publications Bauer, Chauvet, Huber et al.: "Pontin52 and reptin52 function as antagonistic regulators of beta-catenin signalling activity." in: The EMBO journal, Vol. 19, Issue 22, pp. 6121-30, 2000 (PubMed).

Parfait, Giovangrandi, Asheuer et al.: "Human TIP49b/RUVBL2 gene: genomic structure, expression pattern, physical link to the human CGB/LHB gene cluster on chromosome 19q13.3." in: Annales de génétique, Vol. 43, Issue 2, pp. 69-74, 2000 (PubMed).

Wood, McMahon, Cole: "An ATPase/helicase complex is an essential cofactor for oncogenic transformation by c-Myc." in: Molecular cell, Vol. 5, Issue 2, pp. 321-30, 2000 (PubMed).

Salzer, Kubicek, Prohaska: "Isolation, molecular characterization, and tissue-specific expression of ECP-51 and ECP-54 (TIP49), two homologous, interacting erythroid cytosolic proteins." in: Biochimica et biophysica acta, Vol. 1446, Issue 3, pp. 365-70, 1999 (PubMed).

Kanemaki, Kurokawa, Matsu-ura et al.: "TIP49b, a new RuvB-like DNA helicase, is included in a complex together with another RuvB-like DNA helicase, TIP49a." in: The Journal of biological chemistry, Vol. 274, Issue 32, pp. 22437-44, 1999 (PubMed).

Catalog No. ABIN357238
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