Ubiquitin Carboxyl-terminal Esterase L1 (Ubiquitin Thiolesterase) (UCHL1) (N-Term) antibody

Details for Product No. ABIN357509
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Antigen
Synonyms cb358, wu:fc55h08, UCHL1, UCH-L1, park5, pgp9.5, uch-l1, MGC132191, uchl1, AW822034, C88048, PGP 9.5, PGP9.5, R75593, UCHL-1, gad, PARK5, PGP95, Uch-L1
Epitope
N-Term
(40), (20), (12), (12), (7), (6), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(222), (75), (72), (25), (21), (14), (4), (4), (3), (2), (2), (1), (1), (1), (1)
Host
Rabbit
(139), (80), (14), (12), (7), (3)
Clonality
Polyclonal
Conjugate
Un-conjugated
(4), (4), (3), (3), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(197), (100), (65), (64), (31), (17), (17), (10), (4), (3), (2), (1)
Pubmed 5 references available
Quantity 0.4 mL
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Catalog No. ABIN357509
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Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human UCHL1.
Specificity This antibody is specific to UCHL1/PGP9.5 (N-term).
Purification Protein G Chromatography, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name UCHL1 / PGP9.5
Background UCHL1 is a member of a gene family whose products hydrolyze small C-terminal adducts of ubiquitin to generate the ubiquitin monomer. Expression of UCHL1 is highly specific to neurons and to cells of the diffuse neuroendocrine system and their tumors. It is present in all neurons (Doran et al., 1983 [PubMed 6343558]).
Alternate names: Neuron cytoplasmic protein 9.5, PGP 9.5, UCH-L1, Ubiquitin carboxyl-terminal hydrolase isozyme L1, Ubiquitin thioesterase L1
Molecular Weight 24824 Da
Gene ID 7345, 9606
UniProt P09936
Research Area Tags/Labels, Cell/Tissue Markers
Application Notes ELISA: 1/1,000. Western Blot: 1/100-1/500. Immunohistochemistry: 1/50-1/100. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09% (w/v) Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at-20°C for longer.
Expiry Date 12 months
Supplier Images
anti-Ubiquitin Carboxyl-terminal Esterase L1 (Ubiquitin Thiolesterase) (UCHL1) (N-Term) antibody anti-Ubiquitin Carboxyl-terminal Esterase L1 (Ubiquitin Thiolesterase) (UCHL1) (N-Term) antibody
anti-Ubiquitin Carboxyl-terminal Esterase L1 (Ubiquitin Thiolesterase) (UCHL1) (N-Term) antibody (2) anti-Ubiquitin Carboxyl-terminal Esterase L1 (Ubiquitin Thiolesterase) (UCHL1) (N-Term) antibody (Image 2)
Background publications Saigoh, Wang, Suh et al.: "Intragenic deletion in the gene encoding ubiquitin carboxy-terminal hydrolase in gad mice." in: Nature genetics, Vol. 23, Issue 1, pp. 47-51, 1999 (PubMed).

Caballero, Resto, Patturajan et al.: "Interaction and colocalization of PGP9.5 with JAB1 and p27(Kip1)." in: Oncogene, Vol. 21, Issue 19, pp. 3003-10, 2002 (PubMed).

Liu, Fallon, Lashuel et al.: "The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility." in: Cell, Vol. 111, Issue 2, pp. 209-18, 2002 (PubMed).

Nishikawa, Li, Kawamura et al.: "Alterations of structure and hydrolase activity of parkinsonism-associated human ubiquitin carboxyl-terminal hydrolase L1 variants." in: Biochemical and biophysical research communications, Vol. 304, Issue 1, pp. 176-83, 2003 (PubMed).

Maraganore, de Andrade, Lesnick et al.: "Complex interactions in Parkinson's disease: a two-phased approach." in: Movement disorders : official journal of the Movement Disorder Society, Vol. 18, Issue 6, pp. 631-6, 2003 (PubMed).

Validation Images
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