UCHL1 antibody (AA 59-223)

Catalog No. ABIN3022997

Cited in 1 publication. The Rabbit Polyclonal anti-UCHL1 antibody (ABIN3022997) specifically detects UCHL1 in WB and IF. The antibody is reactive with Human samples.

Quick Overview for UCHL1 antibody (AA 59-223) (ABIN3022997)

Target: UCHL1 (Ubiquitin Carboxyl-terminal Esterase L1 (Ubiquitin Thiolesterase) (UCHL1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UCHL1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-UCHL1 Antibody

Binding Specificity: AA 59-223

Sequence: HENFRKKQIE ELKGQEVSPK VYFMKQTIGN SCGTIGLIHA VANNQDKLGF EDGSVLKQFL SETEKMSPED RAKCFEKNEA IQAAHDAVAQ EGQCRVDDKV NFHFILFNNV DGHLYELDGR MPFPVNHGAS SEDTLLKDAA KVCREFTERE QGEVRFSAVA LCKAA

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 59-223 of human PGP9.5/PGP9.5/UCHL1 (NP_004172.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

References for anti-UCHL1 antibody (ABIN3022997)

Yan, Huo, Yang, Zhang, Chu, Liu: "Ubiquitin C-Terminal Hydrolase L1 regulates autophagy by inhibiting autophagosome formation through its deubiquitinating enzyme activity." in: Biochemical and biophysical research communications, Vol. 497, Issue 2, pp. 726-733, (2018) (PubMed).

Target Details for UCHL1

Target: UCHL1 (Ubiquitin Carboxyl-terminal Esterase L1 (Ubiquitin Thiolesterase) (UCHL1))

Alternative Name: UCHL1

Background: The protein encoded by this gene belongs to the peptidase C12 family. This enzyme is a thiol protease that hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. This gene is specifically expressed in the neurons and in cells of the diffuse neuroendocrine system. Mutations in this gene may be associated with Parkinson disease.,HEL-117,HEL-S-53,NDGOA,PARK5,PGP 9.5,PGP9.5,PGP95,SPG79,Uch-L1,UCHL1,Cell Biology & Developmental Biology,Ubiquitin,Ubiquitin-Proteasome Signaling Pathway,Neuroscience,Cell Type Marker,Neurodegenerative Diseases,Dopamine Signaling in Parkinson's Disease,Neuron marker,UCHL1

Molecular Weight: 24 kDa

Gene ID: 7345

UniProt: P09936

Pathways: Feeding Behaviour