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Fas (TNFRSF6)-Associated Via Death Domain (FADD) (pSer191) antibody

Details for Product No. ABIN358126
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Antigen
Synonyms MORT1, Mort1/FADD, Mort1, TNFRSF6
Epitope
pSer191
(30), (30), (14), (13), (10), (9), (8), (3), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(135), (62), (33), (12), (4), (2), (1)
Host
Rabbit
(137), (50), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(7), (7), (7), (4), (4), (4), (4), (4), (4), (4), (4), (4), (3), (3), (3)
Application
ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(135), (95), (43), (40), (23), (17), (8), (6), (2), (2), (2), (1), (1)
Pubmed 3 references available
Quantity 0.4 mL
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
Catalog No. ABIN358126
357.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S191 of mouse FADD.
Specificity This antibody detects FADD pSer191.
Purification Protein G Affinity Chromatography. Then, the antibody fraction is peptide affinity purified in a 2-step procedure with control and phosphorylated peptides. The phospho-specific antibody is eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name FADD
Background FADD is an apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.
Alternate names: FAS-associated death domain protein, FAS-associating death domain-containing protein, GIG3, Growth-inhibiting gene 3 protein, MORT1, Mediator of receptor induced toxicity
Molecular Weight 22960 Da
Gene ID 14082
NCBI Accession 10090
UniProt Q61160
Research Area Cancer, Apoptosis/Necrosis
Application Notes ELISA: 1/1,000. Western Blot: 1/100-1/500. Immunohistochemistry: 1/50-1/100. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09% (w/v) Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at-20°C for longer.
Expiry Date 12 months
Supplier Images
anti-Fas (TNFRSF6)-Associated Via Death Domain (FADD) (pSer191) antibody anti-Fas (TNFRSF6)-Associated Via Death Domain (FADD) (pSer191) antibody
anti-Fas (TNFRSF6)-Associated Via Death Domain (FADD) (pSer191) antibody (2) anti-Fas (TNFRSF6)-Associated Via Death Domain (FADD) (pSer191) antibody (Image 2)
Background publications Hsu, Shu, Pan et al.: "TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways." in: Cell, Vol. 84, Issue 2, pp. 299-308, 1996 (PubMed).

Zhang, Winoto: "A mouse Fas-associated protein with homology to the human Mort1/FADD protein is essential for Fas-induced apoptosis." in: Molecular and cellular biology, Vol. 16, Issue 6, pp. 2756-63, 1996 (PubMed).

Jeong, Bang, Lee et al.: "The solution structure of FADD death domain. Structural basis of death domain interactions of Fas and FADD." in: The Journal of biological chemistry, Vol. 274, Issue 23, pp. 16337-42, 1999 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN358126
357.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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