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phosphorylase Kinase, gamma 2 (Testis) (PHKG2) (N-Term) antibody

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Synonyms PHKG2, MGC145608, zgc:55863, GSD9C, 1500017I02Rik
(34), (15), (12), (10), (5), (1), (1), (1), (1), (1), (1)
Human, Mouse (Murine)
(67), (13), (6), (3), (1), (1), (1), (1), (1)
(53), (17)
(4), (4), (4), (4), (4), (4)
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(65), (42), (41), (9), (6), (2), (2), (1)
Pubmed 5 references available
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Quantity 0.4 mL
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Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human PHKG2.
Isotype Ig
Specificity This antibody detects PHKG2 at N-term.
Purification Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name PHKG2 (PHKG2 Antibody Abstract)
Background Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The STE group (homologs of yeast Sterile 7, 11, 20 kinases) consists of 50 kinases related to the mitogen-activated protein kinase (MAPK) cascade families (Ste7/MAP2K, Ste11/MAP3K, and Ste20/MAP4K). MAP kinase cascades, consisting of a MAPK and one or more upstream regulatory kinases (MAPKKs) have been best characterized in the yeast pheromone response pathway. Pheromones bind to Ste cell surface receptors and activate yeast MAPK pathway.The calcium/calmodulin-dependent kinase (CAMK) group consists of 75 kinases regulated by Ca2+/CaM and close relative family (CAMK, CAMKL, DAPK, MAPKAPK).Synonyms: PHK-gamma-T, PSK-C3, Phosphorylase b kinase gamma catalytic chain testis/liver isoform, Phosphorylase kinase subunit gamma-2
Molecular Weight 46442 Da
Gene ID 5261, 9606
UniProt P15735
Research Area Cancer, Metabolism
Application Notes ELISA 1: 1,000. Western blot 1: 100 - 1: 500. Immunohistochemistry 1: 50 - 1: 100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-phosphorylase Kinase, gamma 2 (Testis) (PHKG2) (N-Term) antibody (ABIN359432) Formalin-fixed and paraffin-embedded human cancer tissue (hepatocarcinoma) reacted wi...
Western Blotting (WB) image for anti-phosphorylase Kinase, gamma 2 (Testis) (PHKG2) (N-Term) antibody (ABIN359432) The anti-PHKG2 Pab is used in Western blot to detect PHKG2 in mouse kidney tissue lys...
Western Blotting (WB) image for anti-phosphorylase Kinase, gamma 2 (Testis) (PHKG2) (N-Term) antibody (ABIN359432) Western blot analysis of PHKG2 (arrow) using PHKG2 Antibody (N-term) . 293 cell lysat...
Background publications Burwinkel, Shiomi, Al Zaben et al.: "Liver glycogenosis due to phosphorylase kinase deficiency: PHKG2 gene structure and mutations associated with cirrhosis." in: Human molecular genetics, Vol. 7, Issue 1, pp. 149-54, 1998 (PubMed).

Maichele, Burwinkel, Maire et al.: "Mutations in the testis/liver isoform of the phosphorylase kinase gamma subunit (PHKG2) cause autosomal liver glycogenosis in the gsd rat and in humans." in: Nature genetics, Vol. 14, Issue 3, pp. 337-40, 1996 (PubMed).

Whitmore, Apostolou, Lane et al.: "Isolation and characterization of transcribed sequences from a chromosome 16 hn-cDNA library and the physical mapping of genes and transcribed sequences using a high-resolution somatic cell panel of ..." in: Genomics, Vol. 20, Issue 2, pp. 169-75, 1994 (PubMed).

Hanks: "Homology probing: identification of cDNA clones encoding members of the protein-serine kinase family." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 84, Issue 2, pp. 388-92, 1987 (PubMed).

Hanks: "Messenger ribonucleic acid encoding an apparent isoform of phosphorylase kinase catalytic subunit is abundant in the adult testis." in: Molecular endocrinology (Baltimore, Md.), Vol. 3, Issue 1, pp. 110-6, 1989 (PubMed).

Catalog No. ABIN359432
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