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Details for Product No. ABIN361693

Discs, Large Homolog 4 (Drosophila) (DLG4) antibody

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PSD95, SAP-90, SAP90, Dlgh4, PSD-95, SAP90A, Sap90, 11, CG1725, CG1730, CPD, DLG, DLG-A, Discs-large, Dlg, Dlg-A, Dlg1, DlgA, Dmel\\CG1725, Drodlg, SAP97, anon-EST:Posey93, anon-WO03040301.258, anon-W ... show more
»Alternatives Rat (Rattus), Cow (Bovine)
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
»Alternatives Un-conjugated
»Alternatives Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)
Pubmed 7 references available
Catalog no. ABIN361693
Quantity 25 µg
185.90 $   Plus shipping costs $45.00
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Immunogen Recombinant rat PSD-95
Clone 6G6
Isotype IgG2a
Specificity Detects a approx. 100 kDa protein corresponding to the molecular mass of PSD-95 on SDS PAGE immunoblots. An additional protein of > 100 kDa is also detected. Additional cross-reactive bands are detected at approx. 75 kDa and 50 kDa in rat and mouse samples.
Sensitivity 1 µg/ml was sufficient for detection of PSD-95 on 20 µg rat brain tissue extract by ECL immunoblot analysis using Goat Anti-Mouse igG:HRP as the secondary.
Purification Protein G Purified
Alternative Name PSD95
Background Synonyms:
Postsynaptic Density protein 95 (PSD95), also known as Synapse associated protein 90 kDa, is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins. PSD95 is a scaffolding protein and is involved in the assembly and function of the postsynaptic density complex. These family members consist of an N-terminal variable segment followed by three amino-terminal PDZ domains, an upstream SH3 domain and an inactive carboxyl-terminal guanylate kinase (GK) domain. The first and second PDZ domain localize NMDA receptors and K+ channels to synapses, and the third binds to neuroligins which are neuronal cell adhesion molecules that interact with b-neurexins and form intercellular junctions. PSD-95 also binds to neuronal nitric oxide synthase, possibly through interactions between PDZ domains present on both proteins. Thus different PDZ domains of PSD-95 might be specialized for distinct Functions.
PSD95 participates in synaptic targeting of AMPA receptors through an indirect manner involving Stargazin and related transmembrane AMPA receptor regulatory proteins (TARPs). The protein is implicated in experience dependent plasticity and plays an indispensable role in learning. Mutations in PSD95 are associated with autism.
Gene ID 29495
NCBI Accession NP_062567.1
UniProt P31016
Research Area Neurology, Organelles
Application Notes Recommended Dilution: 1:250 (WB)
Restrictions For Research Use only
Concentration 1 mg/mL
Buffer PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide
Preservative Sodium azide
Storage -20 °C
Background publications Kennedy: "The postsynaptic density at glutamatergic synapses." in: Trends in neurosciences, Vol. 20, Issue 6, pp. 264-8, 1997 (PubMed).

Irie, Hata, Takeuchi et al.: "Binding of neuroligins to PSD-95." in: Science (New York, N.Y.), Vol. 277, Issue 5331, pp. 1511-5, 1997 (PubMed).

Chetkovich, Bunn, Kuo et al.: "Postsynaptic targeting of alternative postsynaptic density-95 isoforms by distinct mechanisms." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 22, Issue 15, pp. 6415-25, 2002 (PubMed).

Yao, Gainetdinov, Arbuckle et al.: "Identification of PSD-95 as a regulator of dopamine-mediated synaptic and behavioral plasticity." in: Neuron, Vol. 41, Issue 4, pp. 625-38, 2004 (PubMed).

Cao, Viholainen, Dart et al.: "The PSD95-nNOS interface: a target for inhibition of excitotoxic p38 stress-activated protein kinase activation and cell death." in: The Journal of cell biology, Vol. 168, Issue 1, pp. 117-26, 2005 (PubMed).

Cline: "Synaptogenesis: a balancing act between excitation and inhibition." in: Current biology : CB, Vol. 15, Issue 6, pp. R203-5, 2005 (PubMed).

Cai, Li, Rivera et al.: "Interaction between SAP97 and PSD-95, two Maguk proteins involved in synaptic trafficking of AMPA receptors." in: The Journal of biological chemistry, Vol. 281, Issue 7, pp. 4267-73, 2006 (PubMed).

Alternatives for antigen "Discs, Large Homolog 4 (Drosophila) (DLG4)", type "Antibodies"
Hosts (56), (40), (3), (1)
Reactivities (77), (65), (61), (42), (25), (24), (2), (1), (1), (1), (1)
Applications (82), (21), (20), (20), (17), (17), (13), (9), (6), (3), (3), (2), (1), (1)
Conjugates (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (12), (12), (9), (5), (4), (4), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)