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Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 4 (KCNQ4) (AA 2-77) antibody

Details for Product No. ABIN361768, Supplier: Login to see
Antigen
  • KCNQ4
  • k(v)7.4
  • kv7.4
  • DFNA2
  • DFNA2A
  • KV7.4
Epitope
AA 2-77
36
14
7
4
3
2
2
2
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
77
28
23
2
1
1
Host
Mouse
47
17
15
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
Application
Immunocytochemistry (ICC), Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
78
38
37
36
27
26
2
2
1
1
1
Supplier
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Immunogen Fusion protein amino acids 2-77 of human KCNQ4
Clone S43-6
Specificity Detects ~77 kDa.
Sensitivity 1 µg/mL of SMC-309 was sufficient for detection of KCNQ4 in 10 µg of COS-1 cell lysate transiently expressing KCNQ4 by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Purification Protein G Purified
Alternative Name KCNQ4 (KCNQ4 Antibody Abstract)
Background The protein encoded by this gene forms a potassium channel that is thought to play a critical role in the regulation of neuronal excitability (1), particularly in sensory cells of the cochlea (2). The current generated by this channel is inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug (3).
Cellular Localization: Plasma Membrane | Basal Cell Membrane
Gene ID 9132
NCBI Accession NP_004691
UniProt P56696
Research Area Neurology
Pathways
Application Notes Recommended Dilution: WB (1:1000), IHC (1:1000), ICC/IF (1:100), optimal dilutions for assays should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Supplier Images
 image for anti-Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 4 (KCNQ4) (AA 2-77) antibody (ABIN361768) KCNQ4 (S43 6), rat tissue lysate.
Background publications Hernandez, Zaika, Tolstykh et al.: "Regulation of neural KCNQ channels: signalling pathways, structural motifs and functional implications." in: The Journal of physiology, Vol. 586, Issue 7, pp. 1811-21, 2008 (PubMed).

Kharkovets, Dedek, Maier et al.: "Mice with altered KCNQ4 K+ channels implicate sensory outer hair cells in human progressive deafness." in: The EMBO journal, Vol. 25, Issue 3, pp. 642-52, 2006 (PubMed).

Tatulian, Delmas, Abogadie et al.: "Activation of expressed KCNQ potassium currents and native neuronal M-type potassium currents by the anti-convulsant drug retigabine." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 21, Issue 15, pp. 5535-45, 2001 (PubMed).

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