Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

KCNQ4 Products

(Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 4 (KCNQ4))

Categories

The protein encoded by this gene forms a potassium channel that is thought to play a critical role in the regulation of neuronal excitability, particularly in sensory cells of the cochlea. The current generated by this channel is inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. The encoded protein can form a homomultimeric potassium channel or possibly a heteromultimeric channel in association with the protein encoded by the KCNQ3 gene. Defects in this gene are a cause of nonsyndromic sensorineural deafness type 2 (DFNA2), an autosomal dominant form of progressive hearing loss. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

antibodies-online.com stands for high-quality research products. Search, find and order tools with extensive validation data, images, references. Our scientific customer service is always at your disposal if you have any questions about the selection or application of our products.

Featured KCNQ4 Categories

KCNQ4 Antibodies

High quality antibodies with extensive validation data.

KCNQ4 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended KCNQ4 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse
Application WB, ELISA
Validations
  • (1)
  • (1)
Cat. No. ABIN3185286
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IP, IF, ICC, AA
Validations
  • (3)
  • (4)
Cat. No. ABIN361768
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (4)
Cat. No. ABIN563951
Quantity 100 μg
Datasheet Datasheet

Recommended KCNQ4 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1308480
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN3082236
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3130221
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our KCNQ4 products

Marchetta, Möhrle, Eckert, Reimann, Wolter, Tolone, Lang, Wolters, Feil, Engel, Paquet-Durand, Kuhn, Knipper, Rüttiger: "Guanylyl Cyclase A/cGMP Signaling Slows Hidden, Age- and Acoustic Trauma-Induced Hearing Loss." in: Frontiers in aging neuroscience, Vol. 12, pp. 83, (2020) (PubMed).

Jeng, Ceriani, Hendry, Johnson, Yen, Simmons, Kros, Marcotti: "Hair cell maturation is differentially regulated along the tonotopic axis of the mammalian cochlea." in: The Journal of physiology, Vol. 598, Issue 1, pp. 151-170, (2020) (PubMed).

Wolter, Möhrle, Schmidt, Pfeiffer, Zelle, Eckert, Krämer, Feil, Pilz, Knipper, Rüttiger: "GC-B Deficient Mice With Axon Bifurcation Loss Exhibit Compromised Auditory Processing." in: Frontiers in neural circuits, Vol. 12, pp. 65, (2019) (PubMed).

Testai, Barrese, Soldovieri, Ambrosino, Martelli, Vinciguerra, Miceli, Greenwood, Curtis, Breschi, Sisalli, Scorziello, Canduela, Grandes, Calderone, Taglialatela: "Expression and function of Kv7.4 channels in rat cardiac mitochondria: possible targets for cardioprotection." in: Cardiovascular research, Vol. 110, Issue 1, pp. 40-50, (2016) (PubMed).

Sedivy, Joshi, Ghaly, Mizera, Zaloudikova, Brennan, Novotna, Herget, Gurney: "Role of Kv7 channels in responses of the pulmonary circulation to hypoxia." in: American journal of physiology. Lung cellular and molecular physiology, Vol. 308, Issue 1, pp. L48-57, (2015) (PubMed).

Salomonsson, Brasen, Braunstein, Hagelqvist, Holstein-Rathlou, Sorensen: "K(V)7.4 channels participate in the control of rodent renal vascular resting tone." in: Acta physiologica (Oxford, England), Vol. 214, Issue 3, pp. 402-14, (2015) (PubMed).

Svalø, Hansen, Rønn, Sheykhzade, Munro, Rode: "Kv 7 positive modulators reduce detrusor overactivity and increase bladder capacity in rats." in: Basic & clinical pharmacology & toxicology, Vol. 110, Issue 2, pp. 145-53, (2014) (PubMed).

Zhang, Hughes: "KCNQ and KCNE potassium channel subunit expression in bovine retinal pigment epithelium." in: Experimental eye research, Vol. 116, pp. 424-32, (2014) (PubMed).

Iannotti, Silvestri, Mazzarella, Martella, Calvigioni, Piscitelli, Ambrosino, Petrosino, Czifra, Bíró, Harkany, Taglialatela, Di Marzo: "The endocannabinoid 2-AG controls skeletal muscle cell differentiation via CB1 receptor-dependent inhibition of Kv7 channels." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 111, Issue 24, pp. E2472-81, (2014) (PubMed).

Iannotti, Barrese, Formisano, Miceli, Taglialatela: "Specification of skeletal muscle differentiation by repressor element-1 silencing transcription factor (REST)-regulated Kv7.4 potassium channels." in: Molecular biology of the cell, Vol. 24, Issue 3, pp. 274-84, (2013) (PubMed).

Synonyms and alternative names related to KCNQ4

potassium voltage-gated channel subfamily Q member 4 (KCNQ4), potassium channel, voltage gated KQT-like subfamily Q, member 4 (kcnq4), potassium voltage-gated channel subfamily Q member 4 (Kcnq4), potassium voltage-gated channel, subfamily Q, member 4 (Kcnq4), DFNA2, DFNA2A, k(v)7.4, KCNQ4, kv7.4, KV7.4

Protein level used designations for KCNQ4

  • potassium voltage-gated channel, KQT-like subfamily, member 4
  • potassium voltage-gated channel KQT-like protein 4
  • potassium channel KQT-like 4
  • potassium channel subunit alpha KvLQT4
  • potassium voltage-gated channel subfamily KQT member 4
  • KQT-like 4
  • potassium voltage-gated channel, subfamily Q, member 4
  • voltage-gated potassium channel subunit Kv7.4
You are here:
Support