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Sodium Channel, Voltage-Gated, Type IX, alpha Subunit (SCN9A) (AA 1751-1946), (C-Term) antibody

Details for Product No. ABIN361773, Supplier: Login to see
Antigen
  • SCN9A
  • DKFZp459G084
  • Nav1.7
  • PN1
  • mKIAA4197
  • Scn2a
  • ETHA
  • FEB3B
  • GEFSP7
  • NE-NA
  • NENA
  • SFNP
Epitope
AA 1751-1946, C-Term
43
36
8
3
2
2
1
1
1
1
1
1
1
1
1
Reactivity
Hamster, Human, Mouse (Murine), Rat (Rattus)
79
34
33
17
2
2
2
2
Host
Mouse
43
28
11
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
1
Application
Immunocytochemistry (ICC), Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting (WB)
55
36
36
36
25
19
8
2
2
1
1
Supplier
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Immunogen Fusion protein amino acids 1751-1946 (C-terminus) of human Nav1.7
Clone S68-6
Specificity Detects ~230 kDa. No cross-reactivity against other Nav channels.
Sensitivity 1 µg/mL of SMC-314 was sufficient for detection of Nav1.7 in 10 µg of HEK-293 cell lysate transiently expressing Nav1.7 by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Purification Protein G Purified
Alternative Name Nav1.7 (SCN9A Antibody Abstract)
Background Nav1.7 is a voltage-gated sodium channel and plays a critical role in the generation and conduction of action potentials and is thus important for electrical signaling by most excitable cells. Therapeutically, the association of pain insensitivity with the loss of function of a certain sodium channel may have implications. Since Nav1.7 is not present in cardiac muscle or neurons in the central nervous system, blockers of Nav1.7 will not have direct action on these cells and thus can have less side effects than current pain medications. By performing more studies, there is a possibility to develop a new generation of drugs that can reduce the pain intensity in animals (1-3).
Cellular Localization: Membrane | Synapse
Gene ID 6335
NCBI Accession NP_002968
UniProt Q15858
Research Area Signaling, Metabolism
Pathways
Application Notes Recommended Dilution: WB (1:1000), IHC (1:1000), ICC/IF (1:100), optimal dilutions for assays should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Supplier Images
 image for anti-Sodium Channel, Voltage-Gated, Type IX, alpha Subunit (SCN9A) (AA 1751-1946), (C-Term) antibody (ABIN361773) Nav1.7 (S68-6) in T-CHO
 image for anti-Sodium Channel, Voltage-Gated, Type IX, alpha Subunit (SCN9A) (AA 1751-1946), (C-Term) antibody (ABIN361773) Nav1.7 (S68-6), Mouse brain tissue, Amplifier
 image for anti-Sodium Channel, Voltage-Gated, Type IX, alpha Subunit (SCN9A) (AA 1751-1946), (C-Term) antibody (ABIN361773) Nav1.7 (S68-6), Human hippocampus
Product cited in: Ngwainmbi, De, Smith et al.: "Effects of HIV-1 Tat on enteric neuropathogenesis." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 34, Issue 43, pp. 14243-51, 2014 (PubMed).

Background publications Samuels, te Morsche, Lynch et al.: "Compound heterozygosity in sodium channel Nav1.7 in a family with hereditary erythermalgia." in: Molecular pain, Vol. 4, pp. 21, 2008 (PubMed).

Dray: "Neuropathic pain: emerging treatments." in: British journal of anaesthesia, Vol. 101, Issue 1, pp. 48-58, 2008 (PubMed).

Dray, Read: "Arthritis and pain. Future targets to control osteoarthritis pain." in: Arthritis research & therapy, Vol. 9, Issue 3, pp. 212, 2007 (PubMed).