Sodium Channel, Voltage-Gated, Type IX, alpha Subunit (SCN9A) (C-Term), (AA 1751-1946) antibody

Details for Product No. ABIN361773
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Antigen
Synonyms Nav1.7, PN1, mKIAA4197, Scn2a, ETHA, FEB3B, GEFSP7, NE-NA, NENA, SFNP, SCN9A, SCN1A, DKFZp459G084
Epitope
C-Term, AA 1751-1946
(5), (3), (2), (2), (1), (1), (1)
Reactivity
Human, Rat (Rattus)
(38), (27), (26), (13), (13), (2)
Host
Mouse
(31), (8), (2)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunoprecipitation (IP), Immunocytochemistry (ICC), Immunofluorescence (IF)
(21), (19), (18), (10), (6), (2), (2), (2), (1), (1)
Pubmed 3 references available
Catalog no. ABIN361773
Quantity 100 µg
Price
367.40 $   Plus shipping costs $45.00
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  • +1 404 474 4654
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Immunogen Fusion protein AA 1751-1946 (C-terminus) of human Nav1.7
Clone S68-6
Isotype IgG1
Specificity Detects approx. 230 kDa.
Cross-Reactivity (Details) No cross-reactivity against other Nav channels.
Sensitivity 1 µg/mL of SMC-314 was sufficient for detection of Nav1.7 in 10 µg of HEK-293 cell lysate transiently expressing Nav1.7 by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Purification Protein G Purified
Alternative Name Nav1.7
Background Synonyms:
ETHA, hNE Na, NE NA, PN1, SCN9A, voltage gated sodium channel subunit alpha Nav1, peripheral sodium channel 1, neuroendocrine sodium channel
Nav1.7 is a voltage-gated sodium channel and plays a critical role in the generation and conduction of action potentials and is thus important for electrical signaling by most excitable cells. Therapeutically, the association of pain insensitivity with the loss of function of a certain sodium channel may have implications. Since Nav1.7 is not present in cardiac muscle or neurons in the central nervous system, blockers of Nav1.7 will not have direct action on these cells and thus can have less side effects than current pain medications. By performing more studies, there is a possibility to develop a new generation of drugs that can reduce the pain intensity in animals.
Gene ID 6335
NCBI Accession NP_002968.1
UniProt Q15858
Research Area Signaling, Metabolism, Ion Channels, Transporters
Application Notes Recommended Dilution: 1-10 µg/mL (WB), 0.1-1.0 µg/mL (Perox) (IHC/ICC), 1.0-10 µg/mL (IF)
Restrictions For Research Use only
Concentration 1 mg/mL
Buffer PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Supplier Images
anti-Sodium Channel, Voltage-Gated, Type IX, alpha Subunit (SCN9A) (C-Term), (AA 1751-1946) antibody Nav1.7 (S68-6) in T-CHO
anti-Sodium Channel, Voltage-Gated, Type IX, alpha Subunit (SCN9A) (C-Term), (AA 1751-1946) antibody (2) Nav1.7 (S68-6), Mouse brain tissue, Amplifier
anti-Sodium Channel, Voltage-Gated, Type IX, alpha Subunit (SCN9A) (C-Term), (AA 1751-1946) antibody (3) Nav1.7 (S68-6), Human hippocampus
Background publications Dray, Read: "Arthritis and pain. Future targets to control osteoarthritis pain." in: Arthritis research & therapy, Vol. 9, Issue 3, pp. 212, 2007 (PubMed).

Samuels, te Morsche, Lynch et al.: "Compound heterozygosity in sodium channel Nav1.7 in a family with hereditary erythermalgia." in: Molecular pain, Vol. 4, pp. 21, 2008 (PubMed).

General Dray: "Neuropathic pain: emerging treatments." in: British journal of anaesthesia, Vol. 101, Issue 1, pp. 48-58, 2008 (PubMed).

Hosts (31), (8), (2)
Reactivities (38), (27), (26), (13), (13), (2)
Applications (21), (19), (18), (10), (6), (2), (2), (2), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (5), (3), (2), (2), (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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