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Details for Product No. ABIN361773

Sodium Channel, Voltage-Gated, Type IX, alpha Subunit (SCN9A) (C-Term), (AA 1751-1946) antibody

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Antigen
Synonyms Nav1.7, PN1, mKIAA4197, Scn2a, ETHA, FEB3B, GEFSP7, NE-NA, NENA, SFNP, SCN9A, SCN1A, DKFZp459G084
Epitope
»Alternatives C-Term, AA 1751-1946
Reactivity
»Alternatives Human, Rat (Rattus)
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunoprecipitation (IP), Immunocytochemistry (ICC), Immunofluorescence (IF)
Pubmed 3 references available
Catalog no. ABIN361773
Quantity 100 µg
Price
367.40 $   Plus shipping costs $45.00
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Availability Will be delivered in 3 to 4 Business Days
Immunogen Fusion protein AA 1751-1946 (C-terminus) of human Nav1.7
Clone S68-6
Isotype IgG1
Specificity Detects approx. 230 kDa.
Cross-Reactivity (Details) No cross-reactivity against other Nav channels.
Sensitivity 1 µg/mL of SMC-314 was sufficient for detection of Nav1.7 in 10 µg of HEK-293 cell lysate transiently expressing Nav1.7 by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Purification Protein G Purified
Alternative Name Nav1.7
Background Synonyms:
ETHA, hNE Na, NE NA, PN1, SCN9A, voltage gated sodium channel subunit alpha Nav1, peripheral sodium channel 1, neuroendocrine sodium channel
Nav1.7 is a voltage-gated sodium channel and plays a critical role in the generation and conduction of action potentials and is thus important for electrical signaling by most excitable cells. Therapeutically, the association of pain insensitivity with the loss of function of a certain sodium channel may have implications. Since Nav1.7 is not present in cardiac muscle or neurons in the central nervous system, blockers of Nav1.7 will not have direct action on these cells and thus can have less side effects than current pain medications. By performing more studies, there is a possibility to develop a new generation of drugs that can reduce the pain intensity in animals.
Gene ID 6335
NCBI Accession NP_002968.1
UniProt Q15858
Research Area Signaling, Metabolism, Ion Channels, Transporters
Application Notes Recommended Dilution: 1-10 µg/mL (WB), 0.1-1.0 µg/mL (Perox) (IHC/ICC), 1.0-10 µg/mL (IF)
Restrictions For Research Use only
Concentration 1 mg/mL
Buffer PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide
Preservative Sodium azide
Storage -20 °C
Background publications Dray, Read: "Arthritis and pain. Future targets to control osteoarthritis pain." in: Arthritis research & therapy, Vol. 9, Issue 3, pp. 212, 2007 (PubMed).

Samuels, te Morsche, Lynch et al.: "Compound heterozygosity in sodium channel Nav1.7 in a family with hereditary erythermalgia." in: Molecular pain, Vol. 4, pp. 21, 2008 (PubMed).

Dray: "Neuropathic pain: emerging treatments." in: British journal of anaesthesia, Vol. 101, Issue 1, pp. 48-58, 2008 (PubMed).

Alternatives for antigen "Sodium Channel, Voltage-Gated, Type IX, alpha Subunit (SCN9A)", type "Antibodies"
Hosts (28), (8), (2)
Reactivities (35), (25), (23), (13), (13)
Applications (18), (17), (14), (10), (6), (2), (2), (2), (2), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (4), (3), (2), (2), (2), (1)
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