Lysosomal-Associated Membrane Protein 1 (LAMP1) antibody

Details for Product No. ABIN371598
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Synonyms AI196048, CD107a, Lamp-1, LAMPA, LGP120, LEP100
(149), (68), (58), (7), (7), (3), (3), (2)
(97), (85), (31), (2)
Clonality (Clone)
Monoclonal ()
(26), (21), (15), (10), (3), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Immunohistochemistry (Frozen Sections) (IHC (fro)), Flow Cytometry (FACS)
(119), (95), (47), (44), (41), (41), (30), (26), (18), (10), (1), (1)
Pubmed 4 references available
Quantity 0.1 mg
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Catalog No. ABIN371598
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Clone H4A3
Isotype IgG1
Characteristics Synonyms: LAMP-1, LAMPA, LGP120, Lysosome-associated membrane glycoprotein 1, CD107Antigen-like Family Member A
Purification Purified
Alternative Name CD107a / LAMP1
Background CD107a, also known as lysosomal-associated membrane protein 1 (LAMP-1), is a heavilyglycosylated, type I transmembrane protein that constitutes the major sialoglycoproteinson lysosomal membranes. It is a ligand for galaptin, an S-type lectin present inextracellular matrix, through its recognition of acetyllactosamine oligosaccharide chains,and is a ligand for E-selectin-mediated cell adhesion. CD107a is expressed bygranulocytes, T cells, macrophages, dendritic cells, activated platelets, tonsillarepithelium and some tumor cell lines, including U937 and KG1a. It is also a widelyexpressed intracellular antigen. LAMP-1 may function in protecting the inner surface of thelysosomal membrane by forming a barrier to lysosomal hydrolases. The upregulation ofboth CD107a and CD107b on the surface of tumor cell lines has been associated with theirenhanced metastatic potential, where they may increase adhesion to extracellular matrixand endothelium. (Ref. 1-7)
UniProt P11279
Research Area CD Antigens, Surface Receptors of Immune Cells
Application Notes Flow Cytometry: < / = 1 µg/10e6 cells. Immunohistochemistry (Acetone-Fixed, Frozen Tissue Sections). Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.1 mg/mL
Buffer 100 mM Borate Buffered Saline, pH 8.2 without preservatives.
Preservative Without preservative
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
Expiry Date 12 months
Background publications Febbraio, Silverstein: "Identification and characterization of LAMP-1 as an activation-dependent platelet surface glycoprotein." in: The Journal of biological chemistry, Vol. 265, Issue 30, pp. 18531-7, 1990 (PubMed).

Chen, Cha, Yuksel et al.: "Isolation and sequencing of a cDNA clone encoding lysosomal membrane glycoprotein mouse LAMP-1. Sequence similarity to proteins bearing onco-differentiation antigens." in: The Journal of biological chemistry, Vol. 263, Issue 18, pp. 8754-8, 1988 (PubMed).

Sawada, Tsuboi, Fukuda: "Differential E-selectin-dependent adhesion efficiency in sublines of a human colon cancer exhibiting distinct metastatic potentials." in: The Journal of biological chemistry, Vol. 269, Issue 2, pp. 1425-31, 1994 (PubMed).

Sawada, Lowe, Fukuda: "E-selectin-dependent adhesion efficiency of colonic carcinoma cells is increased by genetic manipulation of their cell surface lysosomal membrane glycoprotein-1 expression levels." in: The Journal of biological chemistry, Vol. 268, Issue 17, pp. 12675-81, 1993 (PubMed).

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