Fas (TNFRSF6)-Associated Via Death Domain (FADD) antibody (Sepharose)

Details for Product No. ABIN371639
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Antigen
Synonyms MORT1, Mort1/FADD, Mort1, TNFRSF6
Reactivity
Human
(114), (58), (33), (12), (3), (2), (1)
Host
Mouse
(122), (34), (2)
Clonality (Clone)
Monoclonal ()
Conjugate
Sepharose
(4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (3)
Application
ELISA, Immunoprecipitation (IP), Western Blotting (WB)
(109), (66), (40), (36), (25), (17), (7), (6), (3), (2), (2)
Pubmed 5 references available
Catalog no. ABIN371639
Quantity 50 tests
Price
489.50 $   Plus shipping costs $45.00
Shipping to United States (Change)
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Clone 1A11
Isotype IgG1
Characteristics Synonyms: FAS-associated death domain protein, MORT1, GIG3, FAS-associating deathdomain-containing protein, Mediator of receptor induced toxicity, Growth-inhibiting gene 3protein
Alternative Name FADD
Background Fas-associated death domain (FADD, also known as MORT1) is an important apoptosisadapter molecule involved in the Fas-mediated cell death pathway. FADD associates withthe intracellular domain of FAS (CD95/APO-1) through their respective C-terminal deathdomains (DD). The N-terminal region of FADD contains a death effectors domain (DED)which recruits and binds cytosolic proteins such as FLICE/caspase-8. The subsequentactivation of FLICE by proteolytic cleavage leads to the activation of the caspase-mediated(ICE-related proteases) apoptotic cascade. Overexpression of FADD induces apoptosiswhich is inhibited by CrmA, a specific inhibitor of the interleukin-1a-converting enzyme. FADD has also been shown under certain circumstances to promote cell survival andproliferation. (Ref. 1-6)
UniProt Q13158
Research Area Cancer, Apoptosis/Necrosis
Application Notes ELISA. Immunoprecipitation. Western Blot. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer 2 ml of 100 mM Borate buffered saline, pH 8.2.No preservatives or amine-containing buffer salts added
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Store protected from light. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
Expiry Date 12 months
Background publications Boldin, Varfolomeev, Pancer et al.: "A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain." in: The Journal of biological chemistry, Vol. 270, Issue 14, pp. 7795-8, 1995 (PubMed).

Cleveland, Ihle: "Contenders in FasL/TNF death signaling." in: Cell, Vol. 81, Issue 4, pp. 479-82, 1995 (PubMed).

Muzio, Chinnaiyan, Kischkel et al.: "FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex." in: Cell, Vol. 85, Issue 6, pp. 817-27, 1996 (PubMed).

Newton, Harris, Bath et al.: "A dominant interfering mutant of FADD/MORT1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes." in: The EMBO journal, Vol. 17, Issue 3, pp. 706-18, 1998 (PubMed).

Wieder, Essmann, Prokop et al.: "Activation of caspase-8 in drug-induced apoptosis of B-lymphoid cells is independent of CD95/Fas receptor-ligand interaction and occurs downstream of caspase-3." in: Blood, Vol. 97, Issue 5, pp. 1378-87, 2001 (PubMed).

Hosts (122), (34), (2)
Reactivities (114), (58), (33), (12), (3), (2), (1)
Applications (109), (66), (40), (36), (25), (17), (7), (6), (3), (2), (2)
Conjugates (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (3)
Epitopes (30), (24), (13), (5), (4), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1)
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