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Alstrom Syndrome 1 (ALMS1) (C-Term) antibody

Details for Product No. ABIN374311
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Antigen
Synonyms ALMS1, ALSS, bbb
Epitope
C-Term
(5), (4), (2), (1)
Reactivity
Cow (Bovine), Dog (Canine), Human, Mouse (Murine), Rat (Rattus)
(18), (1)
Host
Goat
(14), (5)
Clonality
Polyclonal
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(12), (12), (6), (2), (2), (2), (1), (1), (1)
Pubmed 1 reference available
Quantity 0.1 mg
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
Catalog No. ABIN374311
357.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Peptide from C Terminus of the protein sequence according to NP_055935.4 Genename: ALMS1
Sequence C-RVTNQLLGRKVPWD
Specificity This antibody detects ALMS1 at C-term.
Purification Ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
Alternative Name ALMS1
Background ALMS1 contains a large tandem-repeat domain that contains no cysteine residues. Mutations in this gene have been associated with Alstrom syndrome. The encoded protein may play a role in hearing, sight, obesity, and liver function. Alternative splice variants have been described but their full length sequences have not been determined.
Alternate names: Alstrom syndrome protein 1, KIAA0328
Gene ID 7840
NCBI Accession NP_055935.4
UniProt Q8TCU4
Research Area Immunology
Application Notes Peptide ELISA: Limit dilution 1: 32000. Western blot: Preliminary experiments gave bands at approx 200kDa and 75kDa in lysatesof Human T cell line Jurkat after 0.3 µg/ml antibody staining. Please note that currently wecannot find an explanation in the literature for the bands we observe given the calculatedsize of 461kDa according to NP_055935.3. Both detected bands were successfully blockedby incubation with the immunizing peptide (and BLAST results with the immunizingpeptide sequence did not identify any other proteins to explain the additional bands). Wewould appreciate any feedback from people in the field - have any results been reportedwith other antibodies/lysates? Have any further splice variants/modified forms beenreported?Immunohistochemistry: 1-3 µg/ml. In paraffin embedded Human Testis shows staining ofcytoplasm in spermatocytes. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Tris buffered saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C.
Expiry Date 12 months
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anti-Alstrom Syndrome 1 (ALMS1) (C-Term) antibody anti-Alstrom Syndrome 1 (ALMS1) (C-Term) antibody
Background publications Collin, Marshall, Ikeda et al.: "Mutations in ALMS1 cause obesity, type 2 diabetes and neurosensory degeneration in Alström syndrome." in: Nature genetics, Vol. 31, Issue 1, pp. 74-8, 2002 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN374311
357.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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